Hepatitis C-related cirrhosis will be a marginal cause of hospital admissions by 2025.

Journal of Hepatology
Sergio Rodríguez-TajesXavier Forns

Abstract

Complications of cirrhosis are the main cause of hospital admissions in liver units. In areas where HCV is prevalent, most of these admissions are attributable to HCV-related cirrhosis (HCV-cirrhosis). This study assessed the impact of direct-acting antivirals (DAA) in the profile of patients with liver disease admitted to a referral liver unit from a university hospital. We registered hospital admissions resulting from cirrhosis to the Liver Unit of the Hospital Clinic of Barcelona, from 2011 to 2014 (pre-DAA period) and from 2015 to 2019 (post-DAA period). From a total of 14,865 hospital admissions, 10,053 resulted from cirrhosis (corresponding to 6,272 patients). The number and proportion of hospital admissions because of HCV-cirrhosis remained stable during the period 2011-2014 (525 per year, 48.8% of the total), but decreased progressively after 2015 (p <0.001), reaching <300 (27.1%) admissions in 2019. Similarly, HCV-cirrhosis accounted for 3,885 inpatient days per year (44.9%) during the pre-DAA period and decreased steadily after 2015 (p >0.001), reaching only 1,909 inpatient days (22%) in 2019. The figures for intensive care unit admissions followed a similar pattern. By means of a slope analysis (binomial regression m...Continue Reading

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Citations

Oct 12, 2020·Journal of Hepatology·Javier CrespoJoaquín Cabezas
Jan 13, 2021·Journal of Endocrinological Investigation·M L MorieriUNKNOWN DARWIN-T2D Network of the Italian Diabetes Society
Aug 10, 2021·World Journal of Gastroenterology : WJG·Pietro TorreMarcello Persico

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