PMID: 11322206Apr 27, 2001Paper

Hepatitis C viral kinetics in difficult to treat patients receiving high dose interferon and ribavirin

Journal of Hepatology
F C BekkeringS W Schalm

Abstract

Hepatitis C viral (HCV) kinetic studies have demonstrated the increased antiviral effect of higher than standard dosages of interferon and of daily treatment schedules. Since interferon has a short half-life, twice-daily administration of interferon may be even more effective. We evaluated the HCV kinetics in daily vs. twice-daily high dose interferon (IFN) therapy in combination with ribavirin in 24 difficult to treat patients. Patients were randomised to 10 MU IFN daily or 5 MU twice-daily for 4 weeks. Interferon efficacy (epsilon) was similar and very high for both groups (range 99.83-99.97%). Clearance of infected cells (beta phase) tended to be slightly faster for patients on 5 MU bd (T1/2 70 vs. 90 h, ns). Clearance of infected cells was strongly related to initial viral load (T1/2 103 vs. 53 h, P = 0.002, for above versus below 2 x 10(6) copies/ml). In this study an additional phase with a temporary rise in viral load was observed between the alpha and the beta phase. Daily high induction dose is associated with nearly complete inhibition of viral replication even in difficult to treat patients. A twice-daily schedule did not lead to further improvement. Clearance rate of infected cells was significantly correlated with ...Continue Reading

Citations

Mar 20, 2004·Journal of Hepatology·Johannes T BrouwerUNKNOWN Benelux Study Group On Treatment Of Chronic Hepatitis C
Jul 20, 2002·Journal of Hepatology·Ruy M Ribeiro, Alan S Perelson
Dec 7, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Wolfgang JessnerPeter Ferenci
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