Hepatitis C Viral Kinetics in Special Populations.

Current Hepatitis Reports
H DahariT J Layden

Abstract

Mathematical models of hepatitis C viral (HCV) kinetics provide a means of estimating the antiviral effectiveness of therapy, the rate of virion clearance and the rate of loss of HCV-infected cells. They have also proved useful in evaluating the extrahepatic contribution to HCV plasma viremia and they have suggested mechanisms of action for both interferon-α and ribavirin. Viral kinetic models can explain the observed HCV RNA profiles under treatment, e.g., flat partial response, biphasic and triphasic viral decay and viral rebound. Current therapy with (pegylated) interferon-α and ribavirin has a poorer success in patients having insulin resistance, hepatic fibrosis, African American ethnicity, HCV/HIV-coinfection, HCV genotype-1 and high baseline viral load. The use of mathematical modeling and statistical analysis of experimental data have been useful in understanding some of these treatment obstacles.

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Citations

Dec 20, 2011·Current Hepatitis Reports·Harel DahariThomas J Layden
Jan 10, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Marina BerenguerF Xavier López-Labrador
Aug 21, 2010·Journal of Viral Hepatitis·J GuedjA S Perelson
Dec 24, 2016·Immunology·Andrew Godkin, Katherine A Smith
Apr 17, 2009·Journal of Virology·Harel DahariSusan L Uprichard

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