Hepatitis C virus core antigen: A simplified treatment monitoring tool, including for post-treatment relapse

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
François M J LamouryTanya L Applegate

Abstract

Simple, affordable diagnostic tools are essential to facilitate global hepatitis C virus (HCV) elimination efforts. This study evaluated the clinical performance of core antigen (HCVcAg) assay from plasma samples to monitor HCV treatment efficacy and HCV viral recurrence. Plasma samples from a study of response-guided pegylated-interferon/ribavirin therapy for people who inject drugs with chronic HCV genotype 2/3 infection were assessed for HCV RNA (AmpliPrep/COBAS Taqman assay, Roche) and HCVcAg (ARCHITECT HCV Ag, Abbott Diagnostics) during and after therapy. The sensitivity and specificity of the HCVcAg assay was compared to the HCV RNA assay (gold standard). A total of 335 samples from 92 enrolled participants were assessed (mean 4 time-points per participant). At baseline, end of treatment response (ETR) and sustained virological response (SVR) visits, the sensitivity of the HCVcAg assay with quantifiable HCV RNA threshold was 94% (95% CI: 88%, 98%), 56% (21%, 86%) and 100%, respectively. The specificity was between 98 to 100% for all time-points assessed. HCVcAg accurately detected all six participants with viral recurrence, demonstrating 100% sensitivity and specificity. One participant with detectable (non-quantifiable) ...Continue Reading

Citations

Apr 28, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Claudio GalliMario Plebani
Nov 2, 2017·Expert Review of Molecular Diagnostics·Jason GrebelyJordan J Feld
May 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrick R HarringtonLisa K Naeger
May 23, 2019·The New England Journal of Medicine·David L Thomas
Apr 11, 2018·Journal of the International AIDS Society·Slim FouratiNiklas Luhmann
Nov 17, 2017·BMC Infectious Diseases·Rosanna W PeelingPhilippa Easterbrook
Feb 27, 2021·Clinics and Research in Hepatology and Gastroenterology·Steven RogerFrançoise Lunel
Apr 1, 2021·Journal of Clinical Laboratory Analysis·Yuhan WangHuang Yuanshuai
Oct 4, 2020·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Wei-Ming ChenSheng-Nan Lu

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