PMID: 11318983Apr 25, 2001Paper

Hepatitis C virus core protein promotes cell proliferation through the upregulation of cyclin E expression levels

Liver
J W ChoM Suh

Abstract

The hepatitis C virus (HCV) core protein is known to play an important role in hepatocarcinogenesis. Recent studies have suggested that the increased proliferation rate of hepatocytes is a major risk factor for the development of hepatocellular carcinoma. In this study, we investigated whether the HCV core protein promotes the cell growth rate through the modulation of cyclin E expression levels. HCV core stable transfectant Rat-1 cell lines showed a markedly increased proliferation rate compared to mock cells. Cyclin E expression and its associated kinase activities were remarkably increased in HCV core stable transfectants. Cyclin E mRNA levels were also upregulated in these cell lines. Our data suggest that the HCV core protein promotes cell proliferation through upregulation of the cyclin E expression levels, implying this property of HCV core protein plays an important role in hepatocarcinogenesis.

References

Dec 1, 1995·Nature Medicine·M StraussJ Bartek
Jan 1, 1995·Acta Oncologica·R L SutherlandE A Musgrove
May 15, 1995·Genes & Development·C J Sherr, J M Roberts
Oct 29, 1993·Biochemical and Biophysical Research Communications·S H ChoY I Lee
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·V DulićG H Stein
Mar 26, 1993·Science·M Ohtsubo, J M Roberts
Jun 18, 1993·Cell·C J Sherr
Dec 6, 1996·Science·C J Sherr
Jan 1, 1997·Molecular and Cellular Biology·D M Bortner, M P Rosenberg
Feb 7, 1997·Cell·A G PaulovichL H Hartwell
Apr 25, 1997·The Journal of Biological Chemistry·R B RayR Ray
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L B Seeff
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M Di Bisceglie
Apr 30, 1999·Analytical Cellular Pathology : the Journal of the European Society for Analytical Cellular Pathology·N H NielsenG Landberg
Sep 28, 1999·Nature·C H SpruckS I Reed
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M HondaS M Lemon

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Citations

Jun 12, 2002·Biochemical and Biophysical Research Communications·Takayuki YamanakaTakefumi Doi
May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rosa M PascaleFrancesco Feo
Apr 23, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sarah L FishmanAndrea D Branch
May 14, 2008·World Journal of Gastroenterology : WJG·Xue-Bing YanChristian Brechot
Jun 22, 2011·Clinics in Liver Disease·Romy ZemelRan Tur-Kaspa
Feb 9, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Yu ShanZhong-min Guo
May 10, 2005·Journal of Cellular Physiology·A AlisiC Balsano
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Takayoshi FukutomiJisu Li
Jan 8, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Ghada M El-NadyTim J Harrison
Sep 27, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Aldona Kasprzak, Agnieszka Adamek
Jan 31, 2007·Journal of Digestive Diseases·Dobrila Stankovic-DjordjevicMilica Pesic
Feb 5, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Saba KhaliqAsim Pervaiz
Aug 2, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T VescovoM Piacentini
Jan 24, 2018·World Journal of Hepatology·Mohammad IrshadKhushboo Irshad
Jan 18, 2018·Proceedings of the National Academy of Sciences of the United States of America·Yan GengPiotr Sicinski
Mar 26, 2003·Cell Death and Differentiation·C Giannini, C Bréchot
Aug 20, 2002·The Journal of General Virology·Mi Nam LeeKyung Lib Jang
Jan 20, 2004·Journal of Biomedical Science·Chih-Fei KaoYan-Hwa Wu Lee
Oct 19, 2012·International Journal of Oncology·Aldona Kasprzak, Agnieszka Adamek
Nov 3, 2020·World Journal of Gastroenterology : WJG·Simmone D'souzaTrushar R Patel

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