PMID: 8938533Nov 1, 1996Paper

Hepatitis C virus density heterogeneity and viral titre in acute and chronic infection: a comparison of immunodeficient and immunocompetent patients

Journal of Hepatology
J P WatsonM F Bassendine

Abstract

Heterogeneities in the buoyant density of hepatitis C virus RNA have been reported in different groups of patients, and have been attributed to differential binding of viral particles to beta-lipoproteins and IgG, and the presence of hepatitis C virus nucleocapsids in circulation. It may be that hepatitis C virus density heterogeneity correlates with the severity of liver disease, hepatitis C virus RNA titre, and the immunocompetence of the patient. We have analysed five immunodeficient patients (one with hypogammaglobulinaemia and selective IgA deficiency, one with X-linked agammaglobulinaemia, three with common variable immunodeficiency) who have been acutely infected with the same batch of intravenous immunoglobulin contaminated with hepatitis C virus (genotype 1a). The course of hepatitis C virus infection in these patients was compared to one immunocompetent patient who presented with acute hepatitis C virus and progressed to chronic disease, and seven immunocompetent patients with chronic hepatitis C. Serum samples were analysed by differential flotation ultracentrifugation in NaCl solution (density 1.063 g/ml). The high and low density fractions were tested for the presence of RNA by RT-PCR. Serum samples were also quant...Continue Reading

References

Jan 1, 1992·Medical Microbiology and Immunology·R ThomssenA Uy
Jul 15, 1991·Annals of Internal Medicine·T L WrightJ R Lake
May 18, 1989·Nature·S Kwok, R Higuchi
Mar 9, 1985·Lancet·C L LeenR Mitchell
Jul 1, 1994·The Journal of General Virology·M KaitoM Kohara
Mar 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M BarreraA Ordinas
Sep 1, 1994·Journal of Hepatology·P L YapP Simmonds
Nov 26, 1994·Lancet·C L van der PoelH W Reesink
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON

❮ Previous
Next ❯

Citations

Sep 8, 2006·Journal of Virology·Jin ZhongFrancis V Chisari
Jan 30, 2010·Lipids in Health and Disease·Inga KuhlmannGerald Rimbach
Dec 14, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Carlo FabrisMario Pirisi
May 23, 2007·Cellular Microbiology·Ursula AndréoAgata Budkowska
Mar 25, 2008·Journal of Medical Virology·Caroline MartinGeoffrey L Toms

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.