Hepatitis C virus genotypes and reinfection of the graft during long-term follow-up in 35 liver transplant recipients

Transplant International : Official Journal of the European Society for Organ Transplantation
L CaccamoD Galmarini

Abstract

To understand the clinical outcome of hepatitis C virus (HCV) recurrence, data from 35 liver transplant recipients who survived more than 6 months were reviewed. The presence of HCV-RNA was evaluated and genotyping was performed. On the basis of alanine aminotransferase (ALT) levels, patients were sorted into four groups. In 20 patients, a chronic elevation in ALT was found; HCV-RNA detection was positive in 17/17 and the following genotypes were found in 15 of them: 1b in ten patients, 2a in four patients, and 3a in one patient. In 11 patients, ALT levels remained normal throughout follow-up; in nine of them HCV-RNA was positive; HCV genotyping was available in eight patients and identified type 1b in two, type 2a in five, and type 3a in another patient. In two patients, ALT fluctuated above and below the upper limits of normality; type 1b HCV-RNA was found in one of them. In two patients, after an initial period of normality, ALT levels showed an abrupt rise; HCV-RNA was positive and type 1b was identified in both patients. Eight patients developed HCV-related deep jaundice and three of them spontaneously recovered. Progressive hepatic injury occurred in eight patients, six with chronic ALT elevation and two showing a late AL...Continue Reading

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Citations

Jul 4, 2001·Journal of Hepatology·P BurraD Martines
Jan 6, 2000·Journal of Hepatology·M U Mondelli, E Silini
Jul 17, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·L CaccamoL R Fassati
Feb 24, 2001·Fundamental & Clinical Pharmacology·F X Caroli-BoscJ C Montet

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