Hepatitis C virus genotypes implicated in mixed cryoglobulinemia

Journal of Medical Virology
Q T NguyenL Guillevin

Abstract

Recent reports suggest that hepatitis C virus (HCV) might be a causative agent of mixed cryoglobulinemia. To determine whether the HCV genotype is a factor implicated in the onset of cryoglobulinemia, genotyping by direct sequencing of polymerase chain reaction products of the 5' non coding region was carried out among 45 HCV-infected patients. Genotypes 1 and 2 were found more prevalent in symptomatic cryoglobulinemia patients. Due to the presence of genotypes 4 and 5 found in this panel of French patients (9.3%), HCV genotyping based on sequence determination is recommended.

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Citations

Jun 8, 2006·Journal of Clinical Microbiology·María Inés GismondiMaría Victoria Preciado
Apr 14, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lenna A MartyakSammy Saab
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Oct 18, 2005·La Presse médicale·P GuilpainL Mouthon
Dec 24, 2004·La Presse médicale·Pascal Cohen, Loïc Guillevin

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