Hepatitis C virus genotypes in chronic hepatitis C of children

Journal of Viral Hepatitis
F BortolottiA Alberti

Abstract

Several hepatitis C virus (HCV) genotypes have been recently identified and genotype 1b has been correlated with severe liver disease and a poor response to interferon therapy. HCV infection in children is an interesting model for evaluation of the relationship between HCV genotypes and liver disease, because of its relatively short duration and the infrequent association with confounding cofactors. We have investigated HCV genotypes, using a dot-blot hybridization assay with genotype-specific probes, in 36 Italian children with chronic hepatitis C who were otherwise well and had no other underlying disease. Only four patients were symptomatic; liver histology, obtained in 33 patients, showed minimal hepatitis in 17 and mild chronic hepatitis in 16. Infection with HCV genotype 1b was found in 55.5% of patients, with a peak prevalence of 83% in children from southern Italy (P < 0.05 vs other regions). The remaining children were infected with HCV genotype 1a (16.6%), genotype 2 (11.1%), and mixed (10.9%) or undetermined (2.7%) genotypes. In one patient, HCV viraemia was never detected. There was no statistically significant correlation between genotype and age, sex, source of infection, alanine aminotransferase pattern and histo...Continue Reading

References

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Citations

Jan 6, 2000·Journal of Hepatology·M Ruiz-MorenoA Millàn
Dec 3, 1998·Gastroenterology·M GuidoF Bortolotti
Aug 29, 1998·Transplantation·S V McDiarmidR W Busuttil
Nov 22, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Ching-Sheng HsuDing-Shinn Chen
Dec 18, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Nabil AntakiPatrick Marcellin
Feb 12, 2014·Epidemiology and Infection·D SimonV R Lunge
Dec 22, 1999·Transfusion·G C OliveiraR Corrêa-Oliveira
Apr 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L BassitA Sáez-Alquézar
Mar 12, 2005·Memórias do Instituto Oswaldo Cruz·Regina M S AmorimCláudia R F Martins
Dec 7, 2007·Memórias do Instituto Oswaldo Cruz·Cláudia Maria Dornelles da SilvaMaria Lucia Rosa Rossetti
Jun 18, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·David KershenobichMarcelo Silva
Mar 26, 2003·The American Journal of Gastroenterology·Maria GuidoMassimo Rugge

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