Hepatitis C virus genotypes in patients on renal replacement therapy

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
T M ChanI K Cheng

Abstract

Chronic hepatitis C virus (HCV) infection is prevalent among patients on renal replacement therapy. Viral genomic differences can contribute to diversities in clinical manifestation. The distribution of HCV genotypes depends on the geographical region and risk factors unique to the patient population. We determined the HCV genotypes in patients on renal replacement therapy in order to define the genotypic profile and examine the relationship between genotype, mode of renal replacement therapy, and the prevalence as well as severity of liver disease. HCV genotypes were determined by restriction fragment length polymorphism and sequencing of the 5'-untranslated region in 21 renal allograft recipients, 29 patients on dialysis, and 26 non-renal failure controls. The most prevalent genotype among patients with renal failure was 1b (78%), followed by 1a (10%) and 6a (8%). 2 renal allograft recipients with 6a infection probably acquired HCV from the same donor. The relative prevalence of HCV genotypes was similar to that of controls. While renal allograft recipients demonstrated more severe liver disease than dialysis patients, the prevalence and severity of chronic hepatitis were similar between patients with 1b and non-1b infection....Continue Reading

Citations

Dec 20, 2000·Transplantation Proceedings·T M ChanK N Lai
Aug 30, 2002·Haemophilia : the Official Journal of the World Federation of Hemophilia·J DelladetsimaA Karafoulidou
Sep 17, 2005·Intervirology·Nancy LeungJohn S Tam
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Svetlozar N Natov, Brian J G Pereira
Feb 26, 2003·Journal of Medical Virology·Renata M PerezAntonio Eduardo B Silva
Dec 19, 2002·The International Journal of Artificial Organs·F FabriziP Martin

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