Abstract
The prevalences of infections with hepatitis C virus (HCV) and hepatitis B virus (HBV) were determined in 110 Thai patients with liver cancer, of whom 80 and 30 had histological diagnoses of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), respectively. Hepatitis B surface antigen was detected in 63.8% of HCC patients and 16.7% of those with CCA. Antibodies to HCV, detected by a third-generation enzyme immunoassay, were found in 11.3% of HCC patients and in no CCA patient. HCV ribonucleic acid (RNA) was detected by polymerase chain reaction in 6 anti-HCV positive patients, and also in 2 patients who had no detectable anti-HCV antibody. A total of 11 patients had evidence of HCV infection, 8 of whom were infected with HCV alone. HCV genotypes were determined in all 8 patients who had HCV RNA; genotype 3a was the most common (62.5%). These results demonstrate that, in Thailand where both HBV and HCV are endemic, HBV infection is still the most important risk factor for HCC, but HCV also has an important role in those without HBV infection. In addition, the genotypic distribution of HCV in HCC in Thailand is similar to that in the general population. No specific association between genotype 1b and HCC was observed.
References
Apr 15, 1992·Cancer·W L ChuangC J Chen
Mar 1, 1992·Journal of Gastroenterology and Hepatology·S D LeeK J Lo
Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J RuizJ Prieto
Feb 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·O S Yenen, S Badur
Apr 14, 1990·Lancet·M C KewG Kuo
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·I SaitoY Ohta
Oct 28, 1989·Lancet·M ColomboM Houghton
Mar 1, 1986·The Journal of Hospital Infection·T S Elliott, G Wallace
Oct 1, 1994·Journal of Clinical Gastroenterology·A M Di BisceglieJ H Hoofnagle
Nov 1, 1994·Journal of Medical Virology·P LuengrojanakulM Mayumi
May 1, 1995·Journal of Clinical Microbiology·J M PawlotskyD Dhumeaux
Jun 1, 1993·Journal of Clinical Microbiology·P SimmondsH Marsden
Aug 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Q HuJ M Vierling
May 1, 1993·Gastroenterologia Japonica·B S Kim, Y M Park
Feb 18, 1995·Lancet·M S De MitriE Pisi
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E SiliniL Salvaneschi
Nov 1, 1994·Journal of Medical Virology·C H ChenD S Chen
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J BukhR H Purcell
Jul 1, 1995·The Journal of General Virology·D B SmithP Simmonds
Citations
Jul 13, 2011·Surgery Today·Masakazu Yamamoto, Shun-ichi Ariizumi
Feb 26, 2000·Human Immunology·S VejbaesyaT Dharakul
Mar 1, 2006·Seminars in Interventional Radiology·Ashwin AnanthakrishnanKia Saeian
Mar 5, 2010·Hybridoma·Seangdeun MoonsomWatchara Kasinrerk
Jul 16, 2011·Hepatitis Research and Treatment·Olivier GalyPierre Hainaut
Apr 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gia L Tyson, Hashem B El-Serag
Mar 17, 2007·Cancer Investigation·Nikolaos K GatselisGeorgios N Dalekos
Sep 26, 2014·Surgery Today·Shun-Ichi Ariizumi, Masakazu Yamamoto
Jun 19, 2008·The American Journal of Gastroenterology·Tae Y LeeDong J Suh
Dec 23, 1998·Infection·Y PoovorawanP Tangkitvanich
Dec 17, 2015·World Journal of Gastroenterology : WJG·Sirio FiorinoElio Jovine
Mar 1, 2003·European Journal of Gastroenterology & Hepatology·Asterios PolizosGeorgios N Dalekos
May 21, 2021·PloS One·Ahmad Adebayo IrekeolaRafidah Hanim Shueb