PMID: 11322205Apr 27, 2001Paper

Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C

Journal of Hepatology
L SerfatyRenée E Poupon

Abstract

Steatosis could be the result of HCV (hepatitis C virus)-induced hypobetalipoproteinemia in patients with chronic hepatitis C. The aim of this study was to assess serum levels of main constituents of betalipoproteins and their relationship with steatosis in patients with chronic hepatitis C without known risk factors for steatosis. One-hundred male patients with untreated biopsy proven non-cirrhotic chronic hepatitis C were included. Twenty-nine of these patients were further treated with interferon. Cholesterol concentration was significantly lower in patients compared to three control groups: reference male population, patients with chronic hepatitis B or with non-alcoholic fatty liver. In multivariate analysis, low apolipoprotein B concentration was an independent factor related with the degree of steatosis. Hypobetalipoproteinemia and degree of steatosis were significantly associated with infection with genotype 3. Among treated patients, only sustained virological responders had a significant increase of cholesterol (5.6 +/- 1 vs. 4.7 +/- 1.3 mmol/l; P = 0.03) and apolipoprotein B concentrations (113 +/- 19 vs. 75 +/- 14 mg/dl; P = 0.05). In chronic hepatitis C, hypobetalipoproteinemia is prevalent and associated with stea...Continue Reading

References

Jan 1, 1992·Medical Microbiology and Immunology·R ThomssenA Uy
Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P J ScheuerG M Dusheiko
Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N BachF Schaffner
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Jan 1, 1995·Annual Review of Nutrition·G Schonfeld
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·G BarbaC Bréchot
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MihmG Ramadori
May 28, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·C FabrisM Pirisi
Jul 1, 1997·The Journal of General Virology·K MoriyaK Koike
Aug 29, 1998·Journal of Hepatology·A J CzajaS B Moore
Feb 18, 1999·Journal of Medical Virology·M MonazahianR Thomssen
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L F HouriganE E Powell
Aug 25, 1999·Journal of Medical Virology·H FujieK Koike
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A SabileG Barba
Dec 28, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L E AdinolfiG Ruggiero
Jul 25, 2000·Journal of Hepatology·L Rubbia-BrandtF Negro

❮ Previous
Next ❯

Citations

Dec 23, 2003·Pathology Oncology Research : POR·Erzsébet SzabóZsuzsa Schaff
Nov 1, 2012·Seminars in Immunopathology·M F BassendineR D G Neely
Feb 16, 2008·Internal and Emergency Medicine·Amedeo LonardoNicola Carulli
Jan 15, 2004·Current Gastroenterology Reports·Vlad RatziuThierry Poynard
Jun 1, 2008·Hepatology International·Ching-Sheng HsuJia-Horng Kao
Nov 26, 2003·Antiviral Research·Fernando Ramalho
May 5, 2004·Journal of Hepatology·Francesco Negro
Apr 14, 2005·Journal of Hepatology·Karim AbidFrancesco Negro
Mar 24, 2004·Trends in Microbiology·Jean-Michel Pawlotsky
Sep 11, 2003·Autoimmunity Reviews·Anna Horváth, Adrienn Bíró
Aug 8, 2002·Journal of Gastroenterology and Hepatology·Jason M HuiJacob George
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexander MontoTeresa L Wright
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dinesh KumarJacob George
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Francesco Negro
Oct 8, 2009·The Journal of Biological Chemistry·Hervé LeratJean-Michel Pawlotsky
Feb 27, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stanislas PolAnais Vallet-Pichard
Aug 18, 2005·Journal of Gastroenterology and Hepatology·Te-Sheng ChangYun-Fan Liaw
May 15, 2007·Journal of Gastroenterology and Hepatology·Michael EconomouEpameinondas Tsianos
Jul 13, 2007·Gut·Stephen Ryder
Apr 4, 2009·PPAR Research·Sébastien DharancyLaurent Dubuquoy
Jan 30, 2010·Lipids in Health and Disease·Inga KuhlmannGerald Rimbach

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Gabriel PerlemuterC Bréchot
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Thierry PoynardJanice Albrecht
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Dinesh KumarJacob George
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
L E AdinolfiG Ruggiero
© 2021 Meta ULC. All rights reserved