PMID: 7545774Jun 1, 1995Paper

Hepatitis C virus infection and genotypes in Japanese hemophiliacs

Liver
K IsobeJ Takamatsu

Abstract

Liver function and antibodies to hepatitis C virus and to human immunodeficiency virus-1 were examined in 195 Japanese patients with hemophilia. One hundred and seventy-three were positive for antibody to HCV and 61 for antibody to human immunodeficiency virus-1. In 63 patients, we examined HCV genotypes according to the double polymerase chain reaction method. Forty cases (63%) were infected with hepatitis C virus with a single genotype, including type 1a in five, type 1b in 21, type 2a in seven and type 2b in seven; 16 (25%) were infected with double genotypes, including types 1a + 1b in 14, types 1b + 2a in one and types 1b+2b in one; and four (6%) were infected with triple genotypes, including types 1a + 1b + 2b in two. Genotype could not be determined in three patients by this method. In the 191 nonhemophiliac patients with chronic hepatitis C, HCV genotyping was as follows: type 1a in 0, type 1b in 121, type 2a in 40 and type 2b in 10 of 171 cases (89.5%) with single infection and types 1b + 2a in five and types 2a + 2b in one of six (5.5%) with double infection. In the remaining 14 patients, genotype could not be determined. Frequent transfusion of domestic and/or imported coagulation factor concentrates probably caused ...Continue Reading

References

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Citations

Apr 4, 2013·Hepatitis Monthly·Fatemeh Jahanbakhsh SefidiFarah Bokharaei-Salim
Mar 11, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuki IshidaHiroyuki Gatanaga
Jul 5, 2003·International Journal of Hematology·Masashi TakiKaneo Yamada
Apr 26, 2015·The Kaohsiung Journal of Medical Sciences·Chung-Feng HuangWan-Long Chuang
Jan 29, 2019·Alimentary Pharmacology & Therapeutics·Panita MettikanontK Rajender Reddy
Feb 9, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·K Samimi-Rad, B Shahbaz
May 29, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·C ParodiP Baré
Dec 15, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Yuki IshidaHiroyuki Gatanaga
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·S TatsunamiK Yamada
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·Y FukudaT Hayakawa
Mar 12, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·H ToyodaH Saito
Mar 1, 2008·Intervirology·Hidenori ToyodaJunki Takamatsu

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