Hepatitis C virus infection causes iron deficiency in Huh7.5.1 cells

PloS One
Carine Fillebeen, Kostas Pantopoulos

Abstract

Patients with chronic hepatitis C virus (HCV) infection frequently develop systemic iron overload, which exacerbates morbidity. Nevertheless, iron inhibits HCV replication in cell culture models and thereby exerts antiviral activity. We hypothesized that the cellular iron status is crucial for the establishment of HCV infection. We show that HCV infection of permissive Huh7.5.1 hepatoma cells promotes an iron deficient phenotype. Thus, HCV leads to increased iron regulatory protein (IRP) activity, accumulation of IRP2 and suppression of transferrin receptor 1 (TfR1) and divalent metal transporter 1 (DMT1) in the host. These data suggest that HCV regulates cellular iron levels to bypass iron-mediated inhibition in viral replication.

References

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Apr 3, 2007·Journal of Hepatology·Carine FillebeenKostas Pantopoulos
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Feb 26, 2011·The Biochemical Journal·Jian Wang, Kostas Pantopoulos
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Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Danyelle N Martin, Susan L Uprichard

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Citations

Oct 8, 2014·AIDS Research and Human Retroviruses·Hsiang-Chun ChangHossein Ardehali
Sep 7, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Andrew J Ghio
Mar 24, 2017·Hemodialysis International·Guy Rostoker, Nosratola D Vaziri
Jun 1, 2018·Annual Review of Nutrition·Marianne Wessling-Resnick
Apr 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Romina MancinelliPiera Valenti
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Vanessa HabergerEberhard Hildt
May 1, 2021·International Journal of Molecular Sciences·Rossana PaganoniMaja Vujic Spasic
Jun 28, 2021·Reviews in Medical Virology·Goutham V Ganesh, Ramkumar K Mohanram

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Methods Mentioned

BETA
Electrophoretic

Software Mentioned

Prism GraphPad

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