Hepatitis C virus infection in a resident elderly population: a 10-year follow-up study

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
F MonicaL Okolicsanyi

Abstract

The natural history of hepatitis C virus infection in the elderly is poorly known. To assess the mortality rate, the progression of liver disease, the hepatitis C virus carrier state and the co-morbidity in a cohort of 35 out of 1,063 anti-hepatitis C virus positive elderly people prospectively followed-up from 1992 to 2002. Liver function tests, hepatitis C virus-RNA analysis, hepatitis C virus genotyping and abdominal ultrasonography were assessed at the beginning of the study, and then, liver function tests and ultrasonography were performed annually during the first 5 years of the follow-up. At the end of the 10-year period, causes of death were recorded, while surviving patients underwent again medical examination, liver function tests and abdominal ultrasonography. Out of 35 patients with a 10-year follow-up, 12 patients died: only 2 (5.7%) from liver-related disease (hepatocellular carcinoma and liver failure), whilst 10 (28.5%) from extrahepatic causes. Out of the two patients dying from liver-related causes, one was hepatitis C virus-RNA positive and one hepatitis C virus-RNA negative. Among the 23 living patients, 13 were hepatitis C virus-RNA positive (56.5%), the majority being infected with genotype 2 (69%); of the...Continue Reading

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Citations

Nov 26, 2008·Age and Ageing·James FrithJulia L Newton
Jan 1, 2014·World Journal of Gastroenterology : WJG·Kazuto Tajiri, Yukihiro Shimizu
Mar 26, 2014·Drugs & Aging·Stephen MalnickSari Tal
Nov 26, 2013·Clinics in Geriatric Medicine·Anupama T Duddempudi, David E Bernstein
Nov 28, 2009·Best Practice & Research. Clinical Gastroenterology·Annarosa Floreani
May 27, 2015·Digestive Diseases and Sciences·Sammy SaabVinay Sundaram
Feb 1, 2012·The American Journal of Gastroenterology·Andres F Carrion, Paul Martin
Dec 17, 2010·World Journal of Hepatology·Ganesh Kumar AnbazhaganThirunalasundari Thiyagarajan

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