PMID: 7545213Apr 1, 1995Paper

Hepatitis C virus infection in Schistosomiasis mansoni in Brazil

Journal of Medical Virology
L M PereiraI G McFarlane

Abstract

The involvement of the hepatitis C virus (HCV) in the severity of liver disease in chronic schistosomiasis was investigated in 215 Brazilian patients with S. mansoni infections, but without evidence of hepatitis B surface antigen (HBsAg). Forty-three had hepatointestinal (HIS) and 172 had hepatosplenic schistosomiasis (HSS), and 135 had compensated (HSSC), and 37 had decompensated (HSSD) liver disease. Fifty-two (24%) were found to have evidence of HCV infection (seropositive for anti-HCV antibodies and/or HCV-RNA). These comprised 35 (95%) of the 37 with HSSD, 16 (12%) of the 135 with HSSC, and 1 (2.4%) of the 43 with HIS, compared with only 1 (2%) of 50 control patients without S. mansoni. Testing of matched liver tissue and peripheral blood mononuclear cells (PBMCs) from 25 patients (6 HSSC and 19 HSSD) with HCV infections showed that 17 (68%) had "active" viral infections, in that negative strand HCV-RNA (the presumed replicative intermediate of the virus) could be detected in liver and/or PBMCs. Among these 25, negative strand HCV-RNA was found in 16 (84%) of the 19 with chronic active hepatitis, but in only 1 (17%) of the 6 with mild or inactive disease (P < 0.01). HCV-RNA was detected in matched spleen specimens from 9 o...Continue Reading

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Citations

May 1, 1997·Transactions of the Royal Society of Tropical Medicine and Hygiene·L M PereiraI G McFarlane
Feb 24, 2001·Journal of Hepatology·Z A AndradeC Trépo
Dec 22, 1999·Microbes and Infection·D W Dunne, E J Pearce
Sep 9, 2008·World Journal of Gastroenterology : WJG·Li Jian WangHai Ning Shi
Feb 19, 2014·Transactions of the Royal Society of Tropical Medicine and Hygiene·J R AndradeRosângela Teixeira
Sep 17, 2013·Revista de saúde pública·Daniele Silva de Moraes Van-LumeSilvia Maria Lucena Montenegro
Aug 6, 2005·Revista Da Sociedade Brasileira De Medicina Tropical·Jose Tavares-NetoJosé Fernando C Figueiredo
Apr 22, 2008·Arquivos De Gastroenterologia·Severino Marcos Borba de ArrudaFernando José do Amaral
Jan 3, 2001·Revista Do Instituto De Medicina Tropical De São Paulo·R T AquinoE G Rolim
May 12, 2017·British Journal of Haematology·Joji ShimonoKoichi Ohshima
Sep 13, 2006·Parasite Immunology·S M Kamal, K El Sayed Khalifa
Nov 30, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Matthew HoareGraeme J M Alexander
Mar 25, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sanaa M KamalNezam H Afdhal
May 29, 2003·MCN. the American Journal of Maternal Child Nursing·Patricia J Bradley, Katherine Helsing Bray
Apr 13, 2006·World Journal of Gastroenterology : WJG·Tetsuro SekiguchiMasatomo Mori
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Feb 5, 2005·Gastroenterología y hepatología·L C Da SilvaF J Carrilho

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