Hepatitis C virus infection may lead to slower emergence of P. falciparum in blood

PloS One
O Ouwe-Missi-Oukem-BoyerS Bisser

Abstract

Areas endemic for Plasmodium falciparum, hepatitis B virus (HBV) and hepatitis C virus (HCV) overlap in many parts of sub-Saharan Africa. HBV and HCV infections develop in the liver, where takes place the first development stage of P. falciparum before its further spread in blood. The complex mechanisms involved in the development of hepatitis may potentially influence the development of the liver stage of malaria parasites. Understanding the molecular mechanisms of these interactions could provide new pathophysiological insights for treatment strategies in Malaria. We studied a cohort of 319 individuals living in a village where the three infections are prevalent. The patients were initially given a curative antimalarial treatment and were then monitored for the emergence of asexual P. falciparum forms in blood, fortnightly for one year, by microscopy and polymerase chain reaction. At inclusion, 65 (20.4%) subjects had detectable malaria parasites in blood, 36 (11.3%) were HBV chronic carriers, and 61 (18.9%) were HCV chronic carriers. During follow-up, asexual P. falciparum forms were detected in the blood of 203 patients. The median time to P. falciparum emergence in blood was respectively 140 and 120 days in HBV- and HBV+ i...Continue Reading

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J BukhR H Miller
Jul 15, 1989·International Journal of Cancer. Journal International Du Cancer·L BrabinY Hinuma
Jan 1, 1988·Biology of the Cell·D MazierM Gentilini
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·J F TrapeB Morault-Peelman
Oct 1, 1995·The American Journal of Tropical Medicine and Hygiene·D Richard-LenobleA Goudeau
Nov 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·E DelaporteB Larouzé
May 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·O TraoreD Richard-Lenoble
Oct 1, 1993·Molecular and Biochemical Parasitology·G SnounouK N Brown
Sep 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·M C DazzaB Larouze
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·L G GuidottiF V Chisari
Jan 1, 1996·The American Journal of Tropical Medicine and Hygiene·P DaubersiesP Druilhe
Jan 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·E BottiusP Druilhe
Jul 8, 1999·Tissue Antigens·F Migot-NabiasA J Georges
Aug 4, 1999·The American Journal of Tropical Medicine and Hygiene·P DeloronP Millet
Feb 16, 2000·The American Journal of Tropical Medicine and Hygiene·O DomarleP Deloron
Jun 3, 2000·Annual Review of Immunology·D TortorellaH L Ploegh
Jul 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·G Gonzalez-AseguinolazaM Tsuji
Aug 22, 2000·The Journal of Experimental Medicine·V PasquettoF V Chisari
Mar 13, 2001·Annual Review of Immunology·L G Guidotti, F V Chisari
Sep 20, 2001·The American Journal of Tropical Medicine and Hygiene·C S SokhnaJ F Trape
Jul 24, 2002·The American Journal of Tropical Medicine and Hygiene·Mazie J BarcusJ Kevin Baird
Oct 5, 2002·Science·Carlos M MorelAyoade M J Oduola
Apr 13, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Amina Amadou HamidouJean-Patrick Louboutin-Croc
Mar 7, 2006·Current Molecular Medicine·Louis Schofield, Ivo Mueller

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Citations

Nov 9, 2011·Nature Medicine·Susanne van SantenAndre J A M van der Ven
Jan 10, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sandrine François-SouquièreMirdad Kazanji
May 27, 2016·PloS One·Irène Pegha MoukandjaFousseyni S Touré Ndouo
Jul 23, 2016·Journal of Medical Virology·Annwyne Houldsworth
Jun 10, 2011·The Journal of Biological Chemistry·Rana ChattopadhyayGuck T Ooi

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