Hepatitis C virus-like particle morphogenesis

Journal of Virology
Emmanuelle BlanchardPhilippe Roingeard

Abstract

Although much is known about the hepatitis C virus (HCV) genome, first cloned in 1989, little is known about HCV structure and assembly due to the lack of an efficient in vitro culture system for HCV. Using a recombinant Semliki forest virus replicon expressing genes encoding HCV structural proteins, we observed for the first time the assembly of these proteins into HCV-like particles in mammalian cells. This system opens up new possibilities for the investigation of viral morphogenesis and virus-host cell interactions.

References

Feb 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P RoingeardJ L Romet-Lemonne
Jun 1, 1994·Journal of Virology·E SantoliniN La Monica
Jan 1, 1997·Journal of Virology·V DeleersnyderJ Dubuisson
Jun 17, 1998·Journal of Virology·K YasuiM Kohara
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Roingeard, C Sureau
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A SabileG Barba
Oct 6, 1999·Current Opinion in Biotechnology·S Schlesinger, T W Dubensky
Jun 22, 2000·The Journal of General Virology·R Bartenschlager, V Lohmann
Dec 9, 2000·Science·K J BlightC M Rice
Mar 7, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A GrakouiC M Rice
Mar 27, 2001·Journal of Virology·P KujalaL Kääriäinen
Aug 3, 2001·Journal of Virology·P MaillardA Budkowska
Sep 1, 2001·Antiviral Research·R Bartenschlager, V Lohmann

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Citations

Mar 16, 2005·Biochemical and Biophysical Research Communications·Viviana FalcónVictor Tsutsumi
Jun 27, 2002·Biochemical and Biophysical Research Communications·Nelson Acosta-RiveroJuan Morales
Jan 8, 2004·Journal of Hepatology·Patrizia Farci
Aug 6, 2002·Current Opinion in Microbiology·Timothy L Tellinghuisen, Charles M Rice
Oct 18, 2002·Trends in Molecular Medicine·Darius MoradpourHubert E Blum
Feb 3, 2007·Journal of Virology·Romuald PatientPhilippe Roingeard
Aug 28, 2003·Journal of Virology·Emmanuelle BlanchardPhilippe Roingeard
Dec 28, 2002·Journal of Virology·Richard MolenkampPeter J Bredenbeek
Mar 1, 2003·Journal of Virology·Emmanuelle BlanchardPhilippe Roingeard
Aug 17, 2004·Journal of Virology·Kevin C KleinJaisri R Lingappa
Apr 28, 2010·Cellular and Molecular Life Sciences : CMLS·Marion DeplaPhilippe Roingeard
Nov 28, 2012·Cellular and Molecular Life Sciences : CMLS·Pauline FerrarisPhilippe Roingeard
May 4, 2011·Journal of Biotechnology·Bradley C Bundy, James R Swartz
Jun 27, 2009·Pharmacology & Therapeutics·Claire GondeauPatrick Maurel
Jan 27, 2009·Biochimica Et Biophysica Acta·John McLauchlan
May 1, 2008·Biochemical and Biophysical Research Communications·Koji IshiiTetsuro Suzuki
Dec 19, 2007·Journal of Viral Hepatitis·P Roingeard, C Hourioux
Sep 11, 2007·The FEBS Journal·Morgane RégeardJacques Le Seyec
Feb 21, 2006·Biochemical and Biophysical Research Communications·Gillian Martinez-DonatoSantiago Dueñas-Carrera
Dec 20, 2005·Biochemical and Biophysical Research Communications·Eiko MatsuoYoshiharu Matsuura
May 28, 2003·Biochemical and Biophysical Research Communications·Viviana FalcónJuan Morales-Grillo
Sep 27, 2003·Biochemical and Biophysical Research Communications·Nelson Acosta-RiveroJuan Morales-Grillo
Sep 27, 2003·Biochemical and Biophysical Research Communications·Viviana FalcónJuan Kouri
May 9, 2007·Gastroenterology·Jean-Michel PawlotskyJohn G McHutchison
Feb 4, 2006·Virology·Birke Bartosch, François-Loïc Cosset
Jan 28, 2018·Applied and Environmental Microbiology·Heather E GoetschKrista R Wigginton
Jun 7, 2003·Antiviral Chemistry & Chemotherapy·Michelle P WalkerZhi Hong

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