Hepatitis C virus-related arthritis

Autoimmunity Reviews
Carlo PalazziIgnazio Olivieri

Abstract

Although asymptomatic joint involvement and arthralgias are frequent in patients with hepatitis C virus chronic infection (HCV), a true arthritis affects only up to 4% of the subjects. HCV-related arthritis (HCVrA) is usually distinguished in two clinical subsets: a more frequent symmetrical polyarthritis (SP), similar to rheumatoid arthritis but much less serious, and an intermittent mono-oligoarthritis (IMO) that involves medium and large sized joints, mainly the ankle. This latter subset is strictly related to the presence of HCV-induced mixed cryoglobulinemia and its cutaneous manifestations, in particular purpura. According to recent reports, anti-CCP antibodies are considered very useful in differentiating the SP subset from rheumatoid arthritis. The treatment of HCVrA is still largely empirical because few studies have analyzed this topic. However, COXIBs, NSAIDs, low doses of corticosteroids, hydroxychloroquine and less frequently methotrexate and penicillamine have been used with partial or complete control of symptoms. On the basis of recent studies, the administration of cyclosporine also seems to be sufficiently safe. The scarcely aggressive nature of HCVrA does not favour the use of anti-TNF agents. Specific anti-v...Continue Reading

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Citations

Mar 25, 2014·World Journal of Gastroenterology : WJG·Deng-Ho YangJenn-Haung Lai
Aug 26, 2014·Expert Opinion on Pharmacotherapy·Carlo PalazziIgnazio Olivieri
Sep 4, 2012·La Revue de médecine interne·M VayssadeM Soubrier
Oct 1, 2009·Pharmacology & Therapeutics·Andreas Suhrbier, Suresh Mahalingam
Sep 1, 2009·Autoimmunity Reviews·Siba P RaychaudhuriM Eric Gershwin
Jun 2, 2009·Rheumatic Diseases Clinics of North America·Dan Buskila
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Oct 30, 2019·International Journal of Molecular Sciences·Yosra BedouiPhilippe Gasque
Jan 30, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Natália Bronzatto MedolagoGiovanni Faria Silva
Jan 29, 2016·World Journal of Gastroenterology : WJG·Carlo PalazziIgnazio Olivieri
Dec 3, 2020·Minerva medica·Elena TreppoSalvatore DE Vita
Oct 19, 2010·Autoimmunity Reviews·Gabriel M SousaAjax M Atta

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