Hepatitis C virus-related internal ribosome entry sites are found in multiple genera of the family Picornaviridae

The Journal of General Virology
Louisa S ChardG J Belsham

Abstract

The internal ribosome entry site (IRES) elements from porcine enterovirus 8 and simian virus 2, two members of a proposed new genus within the family Picornaviridae, were characterized. These IRES elements, in common with the porcine teschovirus 1 IRES, were found to be related functionally and structurally to the IRES element from Hepatitis C virus, a member of the family Flaviviridae. Partial secondary structure predictions were derived and functional assays demonstrated that these IRES elements continued to be active when eIF4G was cleaved and when the activity of eIF4A was blocked.

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Citations

May 28, 2011·Archives of Virology·Daoliang LanXiuguo Hua
Jun 24, 2016·Translation·Regina Cencic, Jerry Pelletier
Sep 29, 2009·Biochimica Et Biophysica Acta·Ying LiuAniko V Paul
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Feb 15, 2008·The Journal of General Virology·Encarnación Martínez-SalasNoemi Fernandez
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Dec 2, 2017·Wiley Interdisciplinary Reviews. RNA·Justine Mailliot, Franck Martin

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