PMID: 7538100Jan 1, 1995Paper

Hepatitis C virus RNA in serum and liver histology in asymptomatic anti-HCV positive subjects

Infection
M ColtortiN Caporaso

Abstract

This study was designed to evaluate serum HCV-RNA, liver histology, and RIBA-II pattern in asymptomatic anti-HCV positive subjects with persistently normal or slightly (i.e. < or = 1.5 times the upper limit of the normal range) elevated serum ALT levels. To this purpose, 22 asymptomatic anti-HCV positive subjects (11 men and 11 women, median age 40, range 21-70 years) underwent liver biopsy and determination of serum HCV-RNA. Positivity for anti-HCV was determined by ELISA-2 and by RIBA-II. Serum HCV-RNA was determined by PCR. Our data show that: 1) 9/22 symptom-free, anti-HCV positive subjects had histological features of chronic liver disease associated with ongoing HCV infection; 2) four subjects had no histological signs of chronic hepatitis and normal serum ALT levels despite positivity for serum HCV-RNA; 3) serum ALT levels did not discriminate HCV-RNA positive subjects with from those without chronic hepatitis; 4) in anti-HCV positive subjects with normal serum ALT levels, a positive RIBA-II pattern was not always predictive of HCV viraemia or chronic hepatitis while an indeterminate RIBA-II pattern was frequently associated with nonspecific liver changes or normal histology. In conclusion, based on these findings, "true...Continue Reading

References

Jul 11, 1991·The New England Journal of Medicine·P FarciR H Purcell
Oct 1, 1991·Journal of Virological Methods·L ImbertiD Primi
Nov 1, 1991·Journal of Medical Virology·G DiodatiA Alberti
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Citations

Jan 1, 1997·Springer Seminars in Immunopathology·P J ScheuerA P Dhillon
Mar 1, 1997·Research in Virology·N CaporasoF Morisco
Jan 6, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F MoriscoN Caporaso
Jan 6, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C PuotiF Montagnese
Jul 9, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C PuotiUNKNOWN Committee on HCV carriers with normal alanine aminotransferase levels of the Italian Association for the Study of the Liver
Jun 9, 2001·European Journal of Gastroenterology & Hepatology·S HervéP Ducrotte
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V DriesH P Dienes

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