Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission

The Journal of Immunology : Official Journal of the American Association of Immunologists
Silvia GiuglianoHugo R Rosen

Abstract

Hepatitis C virus (HCV) is the world's most common blood-borne viral infection for which there is no vaccine. The rates of vertical transmission range between 3 and 6% with odds 90% higher in the presence of HIV coinfection. Prevention of vertical transmission is not possible because of lack of an approved therapy for use in pregnancy or an effective vaccine. Recently, HCV has been identified as an independent risk factor for preterm delivery, perinatal mortality, and other complications. In this study, we characterized the immune responses that contribute to the control of viral infection at the maternal-fetal interface (MFI) in the early gestational stages. In this study, we show that primary human trophoblast cells and an extravillous trophoblast cell line (HTR8), from first and second trimester of pregnancy, express receptors relevant for HCV binding/entry and are permissive for HCV uptake. We found that HCV-RNA sensing by human trophoblast cells induces robust upregulation of type I/III IFNs and secretion of multiple chemokines that elicit recruitment and activation of decidual NK cells. Furthermore, we observed that HCV-RNA transfection induces a proapoptotic response within HTR8 that could affect the morphology of the pl...Continue Reading

References

Apr 1, 1991·The Journal of Cell Biology·C L LibrachS J Fisher
Aug 1, 1989·The Journal of Cell Biology·S J FisherC H Damsky
Jan 6, 2000·Journal of Hepatology·A R ZanettiM L Newell
Feb 5, 2000·The New England Journal of Medicine·A H BirnbaumL Moy
Mar 29, 2001·Nature Immunology·B Moser, P Loetscher
Sep 14, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·A TarradeD Evain-Brion
Sep 5, 2002·Nature Reviews. Immunology·Ashley Moffett-King
Nov 20, 2002·American Journal of Obstetrics and Gynecology·Jan J BrosensIvo A Brosens
Apr 12, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gary L DavisDaniel M Rosenberg
Jun 7, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·UNKNOWN European Paediatric Hepatitis C Virus Network
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xia WuDa-Jin Li
Sep 3, 2005·Immunological Investigations·Marianne J van den HeuvelB Anne Croy
Jul 27, 2006·Nature Reviews. Immunology·Ashley Moffett, Charlie Loke
Sep 9, 2006·Nature Medicine·Philippe Le Bouteiller, Julie Tabiasco
Oct 14, 2006·Science·Veit HornungGunther Hartmann
Mar 17, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chelsea B PolisAmita Gupta
Aug 11, 2007·The Journal of Obstetrics and Gynaecology Research·Ayako HayashidaHiroyoshi Takamizawa
May 20, 2008·American Journal of Obstetrics and Gynecology·Steven A PergamStephen E Hawes
Aug 22, 2008·Immunological Investigations·Vikki M Abrahams
Aug 30, 2008·Journal of Clinical Pathology·B Huppertz
Feb 26, 2009·American Journal of Reproductive Immunology : AJRI·Kaori KogaGil Mor
Aug 12, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andre BoonstraHarry L A Janssen
Aug 28, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Stacy M Horner, Michael Gale
Oct 21, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Latifa T F Yeung, Eve A Roberts
Feb 24, 2010·American Journal of Reproductive Immunology : AJRI·Paulomi B AldoVikki M Abrahams
Feb 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Abigail E MitchellR Palmer Beasley
Jul 30, 2010·Journal of Virology·Gabrielle VieyresJean Dubuisson
Oct 19, 2010·Gastroenterology·Ashwin BalagopalChloe L Thio
Feb 1, 2011·Journal of Reproductive Immunology·Vikki M Abrahams
Feb 4, 2011·The Journal of Infectious Diseases·Jennifer M BabikJoseph M McCune
Mar 18, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Angeles Ruiz-ExtremeraJavier Salmerón
Jun 24, 2011·The New England Journal of Medicine·Hugo R Rosen
Jun 7, 2012·Journal of Assisted Reproduction and Genetics·Ozlem Goruroglu OzturkUmran Kucukgoz
Aug 23, 2012·PLoS Pathogens·Varvara B Zeldovich, Anna I Bakardjiev

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Citations

Jun 20, 2017·Nature Reviews. Immunology·Gil MorAyesha B Alvero
Dec 16, 2016·American Journal of Reproductive Immunology : AJRI·Christopher M NovakIrina Burd
Jan 28, 2017·Scientific Reports·Kjersti M AagaardRebecca Rico-Hesse
Feb 27, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fang YanYunfang Wang
Sep 15, 2017·Pathogens and Disease·Moises León-JuárezEnrique Reyes-Muñoz
Dec 12, 2017·Obstetric Medicine·Jeffrey J Post
Oct 27, 2018·The Journal of Infectious Diseases·Ariane LaroucheHugo Soudeyns
Jan 11, 2020·Obstetrics and Gynecology·Robert M RossiEric S Hall
Jan 11, 2020·Frontiers in Immunology·Henrieta PapúchováTamara Tilburgs
Jul 1, 2017·Journal of Clinical and Translational Hepatology·Marianna G Mavilia, George Y Wu
Aug 7, 2017·F1000Research·Philippe Le Bouteiller, Armand Bensussan
Jun 8, 2018·Archives of Virology·Milene Rocha RibeiroMaurício Lacerda Nogueira
Nov 6, 2015·Journal of Leukocyte Biology·Monica CappellettiSenad Divanovic
Apr 28, 2021·Mucosal Immunology·Evgeniya V Shmeleva, Francesco Colucci

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