PMID: 25798149Mar 24, 2015Paper

Hepatitis C virus seroconversion among HIV-positive men who have sex with men with no history of injection drug use: Results from a clinical HIV cohort

The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale
Ann N BurchellSean B Rourke

Abstract

Internationally, there is a growing recognition that hepatitis C virus (HCV) may be sexually transmitted among HIV-positive men who have sex with men (MSM). To report the first Canadian estimate of HCV seroincidence in 2000 to 2010 and its risk factors among HIV-positive MSM with no known history of injection drug use. Data from the Ontario HIV Treatment Network Cohort Study, an ongoing cohort of individuals in HIV care in Ontario, were analyzed. Data were obtained from medical charts, interviews and record linkage with the provincial public health laboratories. The analysis was restricted to 1534 MSM who did not report injection drug use and had undergone ≥2 HCV antibody tests, of which the first was negative (median 6.1 person-years [PY] of follow-up; sum 9987 PY). In 2000 to 2010, 51 HCV seroconversions were observed, an overall incidence of 5.1 per 1000 PY (95% CI 3.9 to 6.7). Annual incidence varied from 1.6 to 8.9 per 1000 PY, with no statistical evidence of a temporal trend. Risk for seroconversion was elevated among men who had ever had syphilis (adjusted HR 2.5 [95% CI 1.1 to 5.5) and men who had acute syphilis infection in the previous 18 months (adjusted HR 2.8 [95% CI 1.0 to 7.9]). Risk was lower for men who had ini...Continue Reading

Citations

May 22, 2019·Journal of the International AIDS Society·Sophia E SchroederMark Stoové
Aug 31, 2019·Journal of the International AIDS Society·Bernadien M NijmeijerTeunis Bh Geijtenbeek
Jul 29, 2016·AIDS·James Daniel MillardMark Nelson
Dec 18, 2015·Revista Da Sociedade Brasileira De Medicina Tropical·Juliét Silveira HanusLisiane Tuon
Aug 2, 2018·Expert Review of Anti-infective Therapy·Suresh MisraTatyana Kushner
Dec 6, 2019·Sexually Transmitted Infections·Claudia Michelle GabaiAnn Winters
Feb 16, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jim YoungUNKNOWN Canadian Co-infection Cohort Investigators
Nov 21, 2020·The Lancet. Gastroenterology & Hepatology·Fengyi JinAndrew E Grulich

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