Hepatitis C virus therapeutic development: in pursuit of "perfectovir"

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
G J Dore, Jordan J Feld

Abstract

The next decade will be a crucial period in the public health response to hepatitis C virus (HCV) infection. The rapid development of direct-acting antiviral (DAA) therapy for HCV infection has brought considerable optimism to the HCV sector, with the realistic hope that therapeutic intervention will soon provide near-optimal efficacy with well-tolerated short-duration, all-oral regimens. As the zenith in HCV therapeutic development approaches, there remain several key obstacles to the broad implementation of interferon-free DAA regimens. The extent of HCV screening and disease assessment, global and national public health prioritization, and drug pricing will determine the potential impact on disease burden derived from introduction of these exciting new HCV therapies. Public health partnerships and advocacy will be crucial to remove barriers to enhanced HCV treatment access.

References

May 9, 2007·Gastroenterology·Jean-Michel PawlotskyJohn G McHutchison
Nov 13, 2007·Drug and Alcohol Dependence·Jason GrebelyBenedikt Fischer
Jan 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Tarik Asselah, Patrick Marcellin
Apr 1, 2011·The New England Journal of Medicine·Fred PoordadUNKNOWN SPRINT-2 Investigators
Jun 3, 2011·The New England Journal of Medicine·Sanjeev AroraClifford Qualls
Jun 24, 2011·The New England Journal of Medicine·Ira M JacobsonUNKNOWN ADVANCE Study Team
Jun 29, 2012·The New England Journal of Medicine·Paul J Clark, Andrew J Muir
Nov 23, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Khayriyyah Mohd HanafiahSteven T Wiersma
Jun 27, 2013·BMC Infectious Diseases·Yousra A MohamoudLaith J Abu-Raddad
Jul 3, 2013·Nature Reviews. Gastroenterology & Hepatology·Behzad HajarizadehGregory J Dore
Aug 2, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maryam AlaviUNKNOWN Enhancing Treatment for Hepatitis C in Opioid Substitution Settings (ETHOS) Study Group
Aug 2, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeffrey J PostAndrew R Lloyd
Oct 2, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Hemant A ShahJordan J Feld
Jan 17, 2014·The New England Journal of Medicine·Mark S SulkowskiUNKNOWN AI444040 Study Group
Apr 12, 2014·The New England Journal of Medicine·Kris V KowdleyUNKNOWN ION-3 Investigators
Apr 12, 2014·The New England Journal of Medicine·Jordan J FeldBarry Bernstein
Apr 15, 2014·The New England Journal of Medicine·Fred PoordadBarry Bernstein
Apr 15, 2014·The New England Journal of Medicine·Nezam AfdhalUNKNOWN ION-1 Investigators
May 6, 2014·The New England Journal of Medicine·Peter FerenciUNKNOWN PEARL-IV Study
Jun 9, 2014·Lancet·Gary MaartensSharon R Lewin
Jul 12, 2014·Science·Andrew Hill, Graham Cooke
Jul 23, 2014·European Journal of Gastroenterology & Hepatology·David BakerGregory J Dore

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Citations

Jan 16, 2016·The Journal of Infectious Diseases·Timothy D MastroCarol Dukes Hamilton
Nov 14, 2015·Expert Opinion on Drug Discovery·Ivan GentileGuglielmo Borgia
Feb 13, 2016·Journal of Hepatology·Natasha K MartinMatthew Hickman
Feb 6, 2016·The International Journal on Drug Policy·Jason GrebelyUNKNOWN l’International Network on Hepatitis among Substance Users (Réseau international sur l’hépatite chez les consommateurs de dr
Jan 9, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marianne Martinello, Gregory J Dore
Jan 11, 2016·The International Journal on Drug Policy·Jason GrebelyUNKNOWN im Namen vom International Network on Hepatitis care in Substance Users
Mar 8, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Verónica SaludesElisa Martró
Aug 10, 2015·The International Journal on Drug Policy·Marianne Martinello, Gail V Matthews
Aug 19, 2015·The International Journal on Drug Policy·Jason GrebelyUNKNOWN International Network for Hepatitis in Substance Users
Jul 26, 2016·Canadian Journal of Gastroenterology & Hepatology·Selena M SaganJoyce A Wilson
May 6, 2016·Nature Reviews. Gastroenterology & Hepatology·Matthias Götte, Jordan J Feld
Feb 13, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Natasha K MartinMatthew Hickman
Jul 8, 2016·Infectious Diseases and Therapy·Monique R BidellNimish Patel
Sep 20, 2016·Journal of Hepatology·Jordan J Feld, Graham R Foster
Oct 28, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marianne MartinelloGail V Matthews
May 21, 2016·Journal of Gastroenterology and Hepatology·Behzad HajarizadehGregory J Dore
Dec 28, 2016·Journal of Viral Hepatitis·M MartinelloG V Matthews
Aug 24, 2017·Nature Reviews. Gastroenterology & Hepatology·Jason GrebelyGregory J Dore
Nov 2, 2017·Expert Review of Molecular Diagnostics·Jason GrebelyJordan J Feld
Dec 24, 2017·Journal of Viral Hepatitis·B HajarizadehG J Dore
Dec 1, 2018·Future Microbiology·Federico J MensaWei Liu
Sep 22, 2019·International Journal of Molecular Sciences·Mei-Yueh LeeJin-Ching Lee
Oct 1, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Ashley BrownTarik Asselah
Oct 2, 2019·Cold Spring Harbor Perspectives in Medicine·Jeffrey V LazarusAhmed M Elsharkawy
Aug 7, 2017·Journal of the International AIDS Society·Jason GrebelyMarina B Klein
Nov 9, 2017·Journal of the International AIDS Society·Sahar SaeedUNKNOWN Canadian Co-Infection Cohort Study

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