PMID: 7520923May 1, 1994Paper

Hepatitis C virus viremia following clinical resolution of acute hepatitis C

Journal of Hepatology
T GiubertiF Fiaccadori

Abstract

Clinical resolution of acute hepatitis C occurs in a limited proportion of cases. However, the rate of hepatitis C virus persistence remains unclear. For this purpose, we conducted a serial study of 60 patients with hepatitis C virus infection from the early stage of the disease for 24 to 80 months (average 50 months). Fourteen cases who recovered from acute hepatitis were selected from this group for prospective analysis of the behavior of liver enzymes, anti-HCV antibodies (RIBA II, Ortho Diagnostic System) and hepatitis C virus-RNA in serum and in peripheral blood lympho-mononuclear cells by nested polymerase chain reaction. Primers were derived from the 5'-untranslated region of the hepatitis C virus genome and the amplified products were detected by gel electrophoresis and a DNA enzyme immunoassay. All patients except two showed early recovery from acute hepatitis that occurred within 3 months from clinical onset. Transaminase normalization was always preceded by clearance of serum hepatitis C virus-RNA, which remained negative throughout follow-up. During the resolution phase of the disease a progressive decline in the antibody response was observed in most of the patients. At the end of the study anti-C100 was negative i...Continue Reading

References

Mar 1, 1991·Journal of Hepatology·F BortolottiA Alberti
Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M HoughtonQ L Choo
Nov 7, 1990·JAMA : the Journal of the American Medical Association·M J AlterD W Bradley

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Citations

May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Barbara A PiaseckiKyong-Mi Chang
Jan 6, 2000·Journal of Hepatology·P Marcellin
May 16, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·T SantantonioG Pastore
Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Harald HoferPeter Ferenci
Apr 5, 2002·The New England Journal of Medicine·Robin Patel, Jeffrey J Germer
Mar 1, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hidenori ToyodaHidemi Goto
Apr 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael P Busch, Kimberly A Page Shafer
Apr 1, 1995·Histopathology·A P Dhillon, G M Dusheiko
Jan 1, 1996·Annual Review of Microbiology·A C Whelen, D H Persing
May 28, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Eric J GowansDavid C Jackson
Jun 2, 2001·Clinics in Liver Disease·J A Shad, J G McHutchison
Feb 14, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·M E EysterJ J Goedert
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alfredo AlbertiLuisa Benvegnù
Mar 1, 2002·The Cochrane Database of Systematic Reviews·T PoynardJ P Zarski
Aug 29, 2006·World Journal of Gastroenterology : WJG·Takayuki KogureTooru Shimosegawa
Jun 1, 1996·Digestive Diseases and Sciences·C CammàA Craxì
Dec 31, 2014·Clinical and Molecular Hepatology·Yoo-Kyung ChoByung-Cheol Song
Oct 1, 1994·Clinical Microbiology Reviews·J A Cuthbert
Dec 1, 1994·Journal of Clinical Microbiology·M G MarinE Cariani

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