Hepatitis C: What is the best treatment?

Journal of Viral Hepatitis
J F Dillon

Abstract

The treatment of hepatitis C is expensive, difficult and arduous from the patient's perspective. It is similarly difficult for the clinician to decide who and when to treat. If hepatitis C is viewed from the liver's perspective we need only treat those patients who will develop the complications of chronic liver disease within their lifetimes. If we take a more holistic approach, then we have to consider the implications of being a carrier of a potentially transmissible blood borne virus on the patient themselves, their relationships, their families and their sense of wellbeing. There is now evidence of the large impact HCV has on quality of life and we have to consider extra hepatic manifestations of hepatitis C infection, possibly including the syndrome of 'brain fog' recently described. An additional factor that has to be considered in the decision to treat is whether patients perceive hepatitis C as a significant problem for themselves. For some patients, who have chaotic live styles, it is extremely difficult to get them to access healthcare. To then undergo the rigors and tribulations of hepatitis C therapy that is posing no current problem is unlikely to succeed. However, failure to engage these patients with therapy wil...Continue Reading

References

Jun 20, 2001·Gut·J C BoothUNKNOWN Thr Royal College of Physicians of London and the British Society of Gastroenterology
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gary L DavisJanice Albrecht

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Citations

Oct 29, 2013·European Journal of Medicinal Chemistry·Ilkay KüçükgüzelNeerja Kaushik-Basu
Jun 18, 2009·The Journal of Biological Chemistry·Masahiko TakeshitaHiroaki Kataoka
Jan 22, 2008·Nucleic Acids Research·Neerja Kaushik-BasuFrançois Noël
Sep 22, 2007·AJR. American Journal of Roentgenology·Adrian K P LimSimon D Taylor-Robinson
Dec 1, 2006·Expert Review of Pharmacoeconomics & Outcomes Research·Sharon J HutchinsonDavid J Goldberg
Apr 13, 2011·Social Science & Medicine·Thomas Astell-BurtJohn F Dillon
Jul 7, 2007·Archives of Medical Research·Edna Strauss
Feb 16, 2006·Journal of Molecular Biology·Gary LeeYang Li
Dec 23, 2017·Expert Opinion on Investigational Drugs·Guglielmo BorgiaAntonio Riccardo Buonomo

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