PMID: 11340500May 8, 2001Paper

Hepatitis C

Revista Da Sociedade Brasileira De Medicina Tropical
E Strauss

Abstract

It has been estimated that 3% of the world population is infected with the hepatitis C virus. Those who are blood product recipients or have been illicit drug users are at risk. Dental and medical procedures as well as tattooing and acupuncture are also risk factors. Chronic infection occurs in up to 85% of infected cases but they may remain without symptoms during years or even decades, and clinical presentation varies. Determination of anti-HCV in sera is a fairly sensitive tool for the diagnosis, and confirmation requires the identification of HCV-RNA. Staging of the liver disease as well as definition of its present activity can be graded by liver biopsy. The aim of treatment is to stop the progression of the hepatic disease by inhibiting viral replication. Due to the low therapeutic efficacy combined with important side-effects, the administration of interferon and ribavirin have specific indications and contraindications. Predictive factors of therapeutic response, particularly viral load and genotypes of HCV, are useful in the evaluation of patients.

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Citations

Aug 20, 2010·Memórias do Instituto Oswaldo Cruz·Clarice Neuenschwander Lins de MoraisSilvia Maria Lucena Montenegro
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Oct 28, 2011·Revista Da Sociedade Brasileira De Medicina Tropical·Ana Ruth AraújoAdriana Malheiro
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Nov 7, 2019·Pharmacoepidemiology and Drug Safety·Camille Nigri CursinoSabrina Calil-Elias
Jul 2, 2020·Arquivos de neuro-psiquiatria·Maria Rita Polo GasconDecio Diament
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Jan 18, 2008·Revista Da Sociedade Brasileira De Medicina Tropical·Renata Eliane de AvilaJosé Roberto Lambertucci

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