Hepatitis delta virus infects the cells of hepadnavirus-induced hepatocellular carcinoma in woodchucks.

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Natalia FreitasSeverin Gudima

Abstract

Hepatitis delta virus (HDV) is a natural subviral agent of human hepatitis B virus (HBV). HDV enhances liver damage during concomitant infection with HBV. The molecular pathogenesis of HDV infection remains poorly understood. To advance our understanding of the relationship between HDV infection and liver cancer, it was determined whether HDV could infect in vivo the cells of hepadnavirus-induced hepatocellular carcinoma (HCC). Woodchucks (Marmota monax) that were chronically infected with HBV-related woodchuck hepatitis virus (WHV) and already developed HCCs were used as an experimental model. The locations of HCCs within the livers were determined using ultrasound imaging followed by open surgery. One week after surgery the WHV carrier woodchucks were superinfected with WHV-enveloped HDV (wHDV). Six weeks later the animals were sacrificed and HDV replication in normal liver tissues and in center masses of HCCs was evidenced by Northern analysis, real-time polymerase chain reaction assay, and immunohistochemistry. Based on accumulation levels of HDV RNAs and numbers of infected cells, the efficiency of wHDV infection appears to be comparable in most HCCs and normal liver tissues. Cells of WHV-induced HCCs are susceptible to HD...Continue Reading

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Citations

Feb 17, 2015·Pathogens·Rafael AldabeGloria González-Aseguinolaza
Apr 17, 2016·Journal of Hepatology·Camille Sureau, Francesco Negro
Mar 1, 2016·Scientific Reports·Jie-mei YuZhao-Jun Duan
May 10, 2019·Nature Communications·Jimena Perez-VargasFrançois-Loïc Cosset
Apr 29, 2015·World Journal of Hepatology·Zaigham AbbasLubna Shazi
Sep 15, 2017·Virology Journal·Luan Felipo Botelho-SouzaDeusilene Souza Vieira
Jul 12, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sofia ParaskevopoulouChristian Drosten
Jul 3, 2021·Viruses·Jimena Pérez-VargasNatalia Freitas
Jun 25, 2021·World Journal of Gastrointestinal Oncology·Manasa Suresh, Stephan Menne
Mar 12, 2019·Virology·Tetyana LukashSeverin O Gudima

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