Hepatitis E: A disease of reemerging importance

Journal of the Formosan Medical Association = Taiwan Yi Zhi
Siddharth SridharPatrick C Y Woo

Abstract

Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide. Originally considered to be restricted to humans, it is now clear that HEV and HEV-like viruses have several animal reservoirs with complex ecology and genetic diversity, as exemplified by the recent discovery of HEV in dromedaries, a previously underestimated reservoir of zoonotic viruses prior to the emergence of Middle East Respiratory Syndrome coronavirus. Zoonotic foodborne transmission from pigs and feral animals such as wild boar is of increasing importance in the rapidly industrializing countries of the Asia Pacific region. Such zoonotic hepatitis E infection has particular relevance to the increasing population living with immunosuppression, due to the risk of chronic hepatitis E in these patients. Fortunately, major strides have been made recently in the management of chronic hepatitis E patients. Furthermore, an effective vaccine is also available that promises better control of hepatitis E burden in the near future. This review highlights these major recent developments in the epidemiology, treatment, and prevention of hepatitis E.

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Mar 11, 2016·Transfusion Medicine Reviews·Geraldine M WalshWilliam P Sheffield
May 18, 2016·Human Vaccines & Immunotherapeutics·Xing WuZhenglun Liang
Apr 21, 2017·International Journal of Molecular Sciences·Siddharth SridharPatrick C Y Woo
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Mar 17, 2020·Food and Environmental Virology·Sophia BeyerHans-Christoph Selinka
May 24, 2020·Viruses·Sherif Aly El-KafrawyEsam Ibraheem Azhar

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