Hepatitis E: An Underdiagnosed, Emerging Infection in Nonendemic Regions

Journal of Clinical and Translational Hepatology
Steven De Keukeleire, Marijke Reynders

Abstract

Although hepatitis E virus (HEV) is the primary cause of enterically transmitted acute hepatitis and jaundice in developing countries, locally acquired HEV infections are increasing in nonendemic countries. As such, HEV is emerging as an underdiagnosed cause of infection. This report describes three clinically variable cases of HEV infection with unusual clinical presentations. These cases highlight the fact that HEV should be considered in the differential diagnosis of patients with unexplained hepatitis (acute or chronic) with or without extrahepatic manifestations. HEV should also be considered in patients with persistently elevated liver enzymes who have not travelled to known HEV-endemic regions. Lack of knowledge among physicians and an absence of standardized diagnostic tests may result in increased morbidity and mortality from HEV infection.

Citations

Feb 25, 2020·Acta Clinica Belgica·Astrid MuyldermansMarijke Reynders
May 19, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Andrea BeerHans P Dienes

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