Hepatitis E and Acute-on-Chronic Liver Failure

Journal of Clinical and Experimental Hepatology
Ashish Kumar, Vivek Saraswat

Abstract

Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis (AVH) globally. It causes large scale epidemics of AVH across the low- and middle income countries in Asia and Africa, and also causes sporadic cases of AVH in the same geographical region. AVH due to HEV is usually an acute, self-limiting illness, similar in clinical presentation to AVH caused by hepatitis A virus (HAV). When HEV causes AVH in patients of chronic liver disease it may worsen rapidly to a syndrome called acute-on-chronic liver failure (ACLF) leading to very high mortality. Acute deterioration of liver function in a patient with compensated chronic liver disease is the characteristic feature of ACLF. The typical disease course of patients with ACLF is the appearance of organ failure, which progresses to multi-organ failure and death. Many publications have reported HEV as one of the leading causes for ACLF from Asia and Africa, where HEV is endemic. The mortality rate of HEV-related ACLF (HEV-ACLF) ranges from 0% to 67% with a median being 34%. These patients require admission in the intensive care unit and they benefit from a team approach of clinicians with expertise in both hepatology and critical care. The goals of treatment are to prev...Continue Reading

Citations

Jan 7, 2017·World Journal of Gastroenterology : WJG·Chong ChenLiang Chen
Aug 23, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Yijin WangJingmin Zhao
Nov 18, 2015·World Journal of Gastroenterology : WJG·Sara Blasco-AlgoraConrado M Fernández-Rodríguez
May 15, 2019·Expert Review of Anti-infective Therapy·Sébastien LhommeJacques Izopet
Jul 10, 2019·Viruses·Thomas HorvatitsSven Pischke
Nov 21, 2017·Nature Reviews. Disease Primers·Nassim KamarHarry R Dalton
Sep 21, 2017·Gut·Tianzhou WuUNKNOWN Chinese Group on the Study of Severe Hepatitis B (COSSH).
May 8, 2018·Cold Spring Harbor Perspectives in Medicine·Nassim Kamar, Sven Pischke
Sep 6, 2020·International Journal of Molecular Sciences·Tatsuo KandaMitsuhiko Moriyama
Sep 8, 2015·Journal of Viral Hepatitis·Mehnaaz S Khuroo, Mohammad S Khuroo
Jan 26, 2016·World Journal of Hepatology·Avin AggarwalAijaz Ahmed
Apr 28, 2017·Alimentary Pharmacology & Therapeutics·M C DonnellyK J Simpson
Jan 16, 2020·The Indian Journal of Medical Research·Abhik Sinha, Shanta Dutta
Oct 20, 2020·World Journal of Gastroenterology : WJG·Abdullah Tarık Aslan, Hatice Yasemin Balaban
Dec 12, 2020·Journal of Viral Hepatitis·Paul WasuwanichWikrom Karnsakul
Nov 16, 2018·Indian Journal of Medical Microbiology·Runal John StevePriya Abraham
Nov 16, 2018·Indian Journal of Medical Microbiology·Ekta Gupta, Pragya Agarwala
Dec 5, 2017·Euroasian Journal of Hepato-gastroenterology·Ananta ShresthaThupten K Lama
Nov 3, 2020·Frontiers in Microbiology·Vikram ThakurPryanka Thakur
Dec 24, 2021·Zoonoses and Public Health·Julián AcostaAna Laura Cavatorta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Jody OlsonPatrick S Kamath
BioMed Research International
Mario FriasAntonio Rivero-Juarez
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Jody Olson, Constantine Karvellas
© 2022 Meta ULC. All rights reserved