Hepatitis e: molecular virology and pathogenesis

Journal of Clinical and Experimental Hepatology
S K Panda, Satya Pavan Kumar Varma

Abstract

Hepatitis E virus is a single, positive-sense, capped and poly A tailed RNA virus classified under the family Hepeviridae. Enteric transmission, acute self-limiting hepatitis, frequent epidemic and sporadic occurrence, high mortality in affected pregnants are hallmarks of hepatitis E infection. Lack of an efficient culture system and resulting reductionist approaches for the study of replication and pathogenesis of HEV made it to be a less understood agent. Early studies on animal models, sub-genomic expression of open reading frames (ORF) and infectious cDNA clones have helped in elucidating the genome organization, important stages in HEV replication and pathogenesis. The genome contains three ORF's and three untranslated regions (UTR). The 5' distal ORF, ORF1 is translated by host ribosomes in a cap dependent manner to form the non-structural polyprotein including the viral replicase. HEV replicates via a negative-sense RNA intermediate which helps in the formation of the positive-sense genomic RNA and a single bi-cistronic sub-genomic RNA. The 3' distal ORF's including the major structural protein pORF2 and the multifunctional host interacting protein pORF3 are translated from the sub-genomic RNA. Pathogenesis in HEV infect...Continue Reading

Citations

Feb 16, 2017·Food and Environmental Virology·Oksana MykytczukNeda Nasheri
Apr 9, 2020·Frontiers in Microbiology·Neda NasheriAlexander Gill
Dec 2, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wenshi WangQiuwei Pan
Apr 21, 2017·International Journal of Molecular Sciences·Siddharth SridharPatrick C Y Woo
Jul 3, 2021·Viruses·Paolo CapozzaVito Martella
Jul 10, 2021·The Journal of General Virology·Wenjing ZhangTian-Cheng Li

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