Hepatitis E seroprevalence in the United States: Results for immunoglobulins IGG and IGM

Journal of Medical Virology
Causenge CanginJulie A Strunk

Abstract

Previous research identified a decline in hepatitis E virus (HEV) seroprevalence in US in 1988-1994 and 2009-2010. We investigated most recent HEV epidemiology. Using a nationally representative sample (7656 persons in the National Health and Nutrition Examination Survey [NHANES] 2013-2014 and 7124 persons in NHANES 2015-2016), we compared the weighted seroprevalence of HEV (immunoglobulin G [IgG]/immunoglobulin M [IgM]) among people from the US (aged ≧ 6 years) between these two time periods. Sampling-weighted multivariate logistic regression models were used to identify factors associated with HEV seropositivity. The median participant age was 37 years (interquartile range = 17-58 years); 51.17% of them were female. Among US-born individuals, HEV seropositivity (IgG/IgM) increased from 4.5% (95% confidence interval [CI] = 3.5%-5.5%) in 2013-2014 to 8.1% (95%CI = 6.5%-9.7%) in 2015-2016. Recent HEV infection (IgM) has nearly doubled in all US-born people. For participants born in and outside of the US, the overall weighted HEV (IgG/IgM) seropositivity increased from 5% (95%CI = 3.9%-6.1%) during 2013-2014 to 7.7% (95%CI = 7.2%-10.5%) during 2015-2016. In "non-Hispanic Asian" females, HEV seropositivity (IgG/IgM) rose from 8.4%...Continue Reading

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Citations

Feb 25, 2020·European Journal of Gastroenterology & Hepatology·Abhilash PerisettiHemant Goyal
Oct 8, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Wenzhan JingMin Liu
Apr 3, 2021·AIDS Research and Human Retroviruses·Kenneth E ShermanM Tarek Shata
May 11, 2021·World Journal of Gastroenterology : WJG·Daniel CastanedaXaralambos Bobby Zervos
Aug 21, 2021·Journal of Viral Hepatitis·Robert J WongAmit S Chitnis

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