Hepatitis e vaccine to prevent morbidity and mortality during epidemics

Open Forum Infectious Diseases
Kenrad NelsonAlain B Labrique

Abstract

Recurrent, large, waterborne epidemics of hepatitis E virus (HEV) occur regularly after monsoon rains contaminate water supplies in Asia or during humanitarian crises in Africa. These epidemics commonly affect thousands of persons, and it has a high mortality in pregnant women who become infected. Although a subunit HEV vaccine has been developed by Chinese investigators and was found to be highly effective and safe in a large clinical trial, this vaccine is only available in China. Until it is prequalified by the World Health Organization, the vaccine may not be available for use outside of China in low-income countries that lack national vaccine regulatory agencies. In this manuscript, we explore possible strategies for providing access to this potentially important vaccine for international use in responding to epidemics of HEV in low-resource countries.

References

Nov 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David B ReinSteven T Wiersma
Dec 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ting WuNing-Shao Xia
Aug 31, 2012·Emerging Infectious Diseases·Alain B LabriqueKenrad E Nelson
Jan 1, 2012·Asian Pacific Journal of Tropical Biomedicine·Maryam BaqirM Asim Beg

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Citations

Jan 19, 2016·Expert Review of Vaccines·Xin WangQinjian Zhao
Feb 3, 2016·Human Vaccines & Immunotherapeutics·Yueyuan ZhaoPei Liu
Mar 16, 2016·Vaccines·Sina Ogholikhan, Kathleen B Schwarz
Jun 4, 2015·The New England Journal of Medicine·Jun ZhangNing-Shao Xia
Feb 26, 2015·Human Vaccines & Immunotherapeutics·Shao-Wei LiNing-Shao Xia
Jul 28, 2016·Current Opinion in Infectious Diseases·Kenrad E NelsonLisa J Krain
Mar 29, 2019·Journal of Medical Virology·Vargab Baruah, Sujoy Bose
May 8, 2018·Cold Spring Harbor Perspectives in Medicine·Kenrad E NelsonBrittany L Kmush
Dec 23, 2017·Reviews in Medical Virology·Mohamad S HakimQiuwei Pan
Jun 4, 2015·The New England Journal of Medicine·Andrew S AzmanIza Ciglenecki

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