Hepatitis E vaccines: progress and prospects

Drugs
Harald C Worm, Gerhard Wirnsberger

Abstract

Hepatitis E accounts for the major part of enterally transmitted non-A, non-B hepatitis worldwide. Its agent, the hepatitis E virus (HEV), is a small, single-stranded RNA virus. Only one serotype of HEV is recognised. Infection results in protective immunity with long-lived neutralising antibodies. In developing countries with poor sanitary conditions and high population density, hepatitis E causes water-borne epidemics with substantial mortality rates in pregnant women. In addition, more than 50% of cases of acute hepatic failure and sporadic acute hepatitis are due to hepatitis E. The overall prevalence rates of antibodies to the HEV in populations native to these areas rarely exceed 25%. Hence, many individuals remain susceptible to hepatitis E infection, making hepatitis E an important public health concern. In this context, the development of an HEV vaccine is warranted. Because HEV does not grow adequately in cell cultures the development of a vaccine based on inactivated or attenuated whole-virus particles is not feasible. HEV vaccines currently under study are based on recombinant proteins derived from immunogenic parts of the HEV capsid gene. Other approaches such as DNA-based vaccines or transgenic tomatoes have also ...Continue Reading

References

Jun 6, 1992·Lancet·S C RobsonD Bradley
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M KaurM Carl
Nov 1, 1991·Journal of Virology·P O YarboughG R Reyes
Apr 1, 1990·British Medical Bulletin·D W Bradley
Jul 1, 1985·Journal of Medical Virology·E H BelabbesG Illoul
May 1, 1993·Virology·Y E KhudyakovH Margolis
Apr 22, 1995·Lancet·M S KhurooS Jameel
Feb 1, 1995·The Journal of Infectious Diseases·V A ArankalleR H Purcell
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·S A TsarevR H Purcell
Jun 1, 1994·Journal of Medical Virology·S A TsarevR H Purcell
May 22, 1993·Lancet·M S KhurooS Jameel
Jan 1, 1993·Journal of Medical Virology·M R WallaceE C Oldfield
Aug 1, 1993·Applied and Environmental Microbiology·N JothikumarP Khanna
Jun 1, 1996·The American Journal of Tropical Medicine and Hygiene·A L CorwinK C Hyams
Oct 11, 1996·Journal of Chromatography. B, Biomedical Applications·C P McAteeK R Williams
Jan 1, 1996·Scandinavian Journal of Infectious Diseases·A KoshyA L Richards
Jan 1, 1997·Journal of Viral Hepatitis·S H HussainiJ G O'Grady
Jun 1, 1997·Journal of Clinical Microbiology·J MengJ Pillot
Jan 1, 1997·Vox Sanguinis·C H WangS Y Tschen
Jul 1, 1997·Research in Virology·S BenjellounA Benslimane
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·X J MengS U Emerson
Mar 14, 1998·Protein Expression and Purification·R A RobinsonR H Purcell
Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E E MastR H Purcell
Apr 18, 1998·The American Journal of Tropical Medicine and Hygiene·P CoursagetR Roue
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C WuS D Lee
Jul 11, 1998·Journal of Viral Hepatitis·V A ArankalleK Banerjee

❮ Previous
Next ❯

Citations

Jan 11, 2008·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·UNKNOWN Arbeitskreis Blut des Bundesministeriums für Gesundheit
Mar 3, 2007·The New England Journal of Medicine·Mrigendra Prasad ShresthaBruce L Innis
Jun 30, 2005·Animal Health Research Reviews·S Denise Goens, Michael L Perdue
Nov 1, 2007·Journal of Applied Animal Welfare Science : JAAWS·Andrew Knight
Nov 12, 2010·Journal of Virology·Li XingR Holland Cheng
Jan 1, 2008·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Georg PauliCarl-Heinz Wirsing von König
Apr 29, 2015·Current Opinion in Virology·Shaowei LiNingshao Xia
Jun 4, 2005·International Journal of Immunogenetics·R AroraR Bamezai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Medicina clínica
María Teresa Pérez-Gracia, Manuel Rodríguez-Iglesias
Wiener klinische Wochenschrift
Harald C WormGerald Brandstätter
World Journal of Hepatology
Eyasu H Teshale, Dale J Hu
© 2022 Meta ULC. All rights reserved