Hepatitis E virus-associated cryoglobulinemia in solid-organ-transplant recipients

Liver International : Official Journal of the International Association for the Study of the Liver
Olivier MarionNassim Kamar

Abstract

An association between hepatitis E virus (HEV) infection and cryoglobulinemia has been suggested. The aims of this study were to assess the prevalence of cryoglobulinemia during HEV infection in solid-organ-transplant (SOT) recipients, to describe its outcomes under ribavirin therapy and to evaluate its effects on kidney function and histology. Between November 2005 and June 2016, 128 cases of HEV infection were diagnosed among SOT recipients followed in our institution. Cryoglobulinemia data obtained from 66 patients during acute-phase HEV and 51 patients during chronic-phase HEV were compared to a historical control group of 89 SOT recipients without HEV markers. Cryoglobulins were also monitored in a group of 43 patients treated by ribavirin. The prevalence of cryoglobulinemia was increased in HEV-infected SOT patients during a chronic phase (52.9%) compared to HEV-infected SOT patients at acute phase (36.4%) (P = .1) and to HEV-negative SOT patients (23.6%) (P < .001). HEV infection was identified as an independent predictive factor for cryoglobulinemia (OR 2.3, CI 95%: 1.17-4.55, P = .02). After ribavirin therapy and HEV clearance, the prevalence of cryoglobulin was significantly decreased from 53.5% to 20.9% (P = .003). K...Continue Reading

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Citations

Oct 12, 2019·Clinical and Molecular Hepatology·Fotios S FousekisDimitrios K Christodoulou
Dec 7, 2019·Neurology. Neuroimmunology and Neuroinflammation·Paolo RipellinoClaudio Gobbi
Jul 31, 2019·Current Opinion in Infectious Diseases·Philippe Colson, Claire Decoster
Jan 30, 2020·Journal of Clinical Medicine·Sébastien LhommeNassim Kamar
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Feb 16, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Maureen WhitsettIra Jacobson
May 15, 2019·Expert Review of Anti-infective Therapy·Sébastien LhommeJacques Izopet
Dec 11, 2020·Journal of Viral Hepatitis·Myrte GorrisJoep de Bruijne
Jan 29, 2021·World Journal of Gastroenterology : WJG·Chrong-Reen Wang, Hung-Wen Tsai

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