Hepatitis E Virus in Cambodia: Prevalence among the General Population and Complete Genome Sequence of Genotype 4

PloS One
Hiroko YamadaJunko Tanaka

Abstract

Hepatitis E virus (HEV) is a growing public health problem in many countries. In this study, we investigated HEV seroprevalence among the general population in the Siem Reap province, Cambodia, and performed HEV genetic analysis with the aim to develop an HEV prevention strategy. This seroepidemiological cross-sectional study conducted from 2010 to 2014 included 868 participants from four different locations in Siem Reap province, Cambodia. They answered questionnaires and provided blood samples for the analysis of hepatitis virus infections. Among the participants (360 men and 508 women; age range, 7-90 years), the prevalence of anti-HEV IgG was 18.4% (95% confidence interval: 15.9-21.0); HEV RNA was detected in two participants (0.23%) and was classified as genotype 3 and 4. Full-length genome of the genotype 4 isolate, CVS-Sie10, was sequenced; it contained 7,222 nucleotides and three ORFs and demonstrated high sequence identity with the swine China isolates swGX40 (95.57%), SS19 (94.37%), and swDQ (91.94%). Multivariate logistic regression analysis revealed that men, elderly people, and house workers were risk groups significantly associated with the positivity for anti-HEV IgG. This is the first report on the detection of ...Continue Reading

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Citations

Jun 12, 2018·Zoonoses and Public Health·Silvia E TritzMaude Pauly
May 22, 2019·Viruses·Putu Prathiwi PrimadharsiniHiroaki Okamoto
Jul 2, 2021·FEMS Microbiology Letters·Renata ZorzettoLuiz Carlos Kreutz

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Datasets Mentioned

BETA
LC042232
EU676172
SS19
JX855794
AB291964
Japan
AB253420
DQ145797
DQ145792

Methods Mentioned

BETA
blood drawn
PCR

Software Mentioned

MAC
GENETYX
JMP

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