Hepatitis E virus in sheep in Italy

Transboundary and Emerging Diseases
Vittorio SarcheseBarbara Di Martino

Abstract

Hepatitis E virus (HEV) is the leading cause of human enterically transmitted viral hepatitis occurring around the world both as outbreaks and as sporadic cases. The accumulating literature indicates that domestic pigs and wild boars are the main reservoirs of genotype 3 and genotype 4 for human infections in industrialized countries. However, the recent identification of HEV from various animal species poses additional potential concerns for HEV zoonotic infection. In this study, the role of sheep as potential host of hepatitis E virus (HEV) was investigated. By screening 192 sheep from seven farms located in Abruzzo Region (Southern Italy), HEV-specific antibodies were detected in the sera of 41 animals (21.3%) whilst the RNA of HEV, genotype 3, was detected in 20 faecal (10.4%) and three serum samples (1.6%). Upon sequence analyses of a partial ORF2 gene region of eight HEV positive samples, the sheep sequences all grouped together within HEV genotype 3 subtype c, being most closely related to HEV strains identified in goat and wild boar from Abruzzo. This is the first study that demonstrates, serologically and molecularly, the presence of HEV in sheep population in a European country.

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Citations

Feb 25, 2020·Transboundary and Emerging Diseases·João R MesquitaMaria S J Nascimento
May 22, 2019·Viruses·Scott P Kenney
Apr 5, 2020·International Journal of Environmental Research and Public Health·Marcello IaconelliGiuseppina La Rosa
May 22, 2019·Viruses·Putu Prathiwi PrimadharsiniHiroaki Okamoto
Jul 31, 2019·Current Opinion in Infectious Diseases·Philippe Colson, Claire Decoster
Feb 13, 2021·Viruses·Shaoli Lin, Yan-Jin Zhang
Dec 16, 2020·Animals : an Open Access Journal From MDPI·Andrea PalombieriBarbara Di Martino
Dec 17, 2020·Viruses·Radka DziedzinskaPetra Vasickova
Jul 3, 2021·Viruses·Anna Rosa Garbuglia The Other Members Of The Hev Outbreak Working Group
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Danny Franciele da Silva Dias MoraesMaria São José Nascimento

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