Hepatitis E virus infection during pregnancy

Virology Journal
Chunchen WuJianbo Xia

Abstract

Hepatitis E virus (HEV) generally causes self-limiting viral hepatitis. However, in pregnant women, HEV infection can be severe and has been associated with up to 30% mortality in the third trimester. Additionally, HEV infection in pregnancy is also associated with high rates of preterm labor and vertical transmission. HEV is now recognized as a global health problem in both developing and industrialized countries. HEV can be transmitted via the fecal-oral route, zoonotic route, and blood transfusion route. An altered immune status, hormonal levels, and viral factors may be related to the severity of the disease. Currently, no established treatment is available for HEV in pregnant women. A Chinese vaccine has been demonstrated to be protective against HEV in the general population and seems to be safe in pregnancy; however, its safety and efficacy in a large population of pregnant women remain to be determined. This review summarizes the current knowledge about HEV infection during pregnancy and focuses on the epidemiology, clinical manifestations, mechanisms underlying severe liver injury, and management and prevention of HEV infection during pregnancy. Considering that HEV infection during pregnancy may result in poor outcome...Continue Reading

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Citations

Oct 8, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Wenzhan JingMin Liu
Jan 19, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rosy SultanaKaiissar Mannoor
May 1, 2021·Scientific Reports·Mariane Fráguas-EggenschwilerHeiner Niemann
Jun 8, 2021·Zeitschrift für Rheumatologie·Larissa Valor-MéndezArnd Kleyer
Aug 4, 2021·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Hai-Yan SunDa-Wei Cui
Aug 10, 2021·World Journal of Gastroenterology : WJG·Pietro TorreMarcello Persico
Sep 21, 2021·Frontiers in Medicine·Delphine ParraudFlorence Abravanel
Oct 12, 2021·Applied Microbiology and Biotechnology·Beibei ZhangEn-Min Zhou
Dec 22, 2021·Journal of Biomolecular Structure & Dynamics·Meenakshi ChaudharyDeepak Sehgal
Feb 1, 2022·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Patrick Behrendt, Heiner Wedemeyer

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