PMID: 697229Oct 1, 1978Paper

Hepatitis from intravenous high-dose oxacillin therapy: findings in an adult inpatient population

Annals of Internal Medicine
I M Onorato, J L Axelrod

Abstract

A retrospective review of all patients who received oxacillin intravenously in doses greater than 6 g/day was done. Eight patients in whom oxacillin-associated hepatitis developed were found and compared with a control group of 46 patients who had received high-dose oxacillin and in whom oxacillin-associated hepatitis did not develop. The latent period to development of typical symptoms of hepatitis varied from 2 to 21 days. Laboratory abnormalities were compatible with anicteric hepatitis and reverted to normal after withdrawal of the drug. Oxacillin hepatitis most like represents a hypersensitivity reaction. We recommend that routine liver chemistries be done regularly in all patients receiving high-dose intravenous oxacillin.

Citations

Jan 1, 1993·International Journal of Antimicrobial Agents·M J Hicks, C M Flaitz
Aug 7, 1982·Lancet·R AmmannM Reinhardt
Mar 1, 2008·Journal of Paediatrics and Child Health·Chun-Yi LeeChing-Shiang Chi
Nov 1, 1987·Antimicrobial Agents and Chemotherapy·K A Neftel, U Hübscher
Nov 20, 2013·Antimicrobial Agents and Chemotherapy·Florent ValourUNKNOWN Lyon BJI Study Group
Apr 3, 2020·Expert Opinion on Drug Safety·Carla BastidaAntoni Torres
Jan 1, 1996·Digestive Diseases and Sciences·M E PrestiB A Neuschwander-Tetri
Jul 1, 1985·Drug Intelligence & Clinical Pharmacy·S M Eggleston, M M Belandres
Apr 2, 1999·Clinical Orthopaedics and Related Research·J T MaderJ Calhoun
Jan 1, 1985·Acta Medica Scandinavica·P TaurisK Albertsen
Jan 1, 1985·Scandinavian Journal of Infectious Diseases·F BengtssonT Aberg
Jul 26, 2003·Clinics in Liver Disease·Michael Thiim, Lawrence S Friedman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Annals of Internal Medicine
C TaylorC Craig
The Journal of Pediatrics
R N Olans, L B Weiner
Archives of Internal Medicine
T J Halloran, M D Clague
Digestive Diseases and Sciences
C N Williams, D A Malatjalian
Annals of Internal Medicine
A R MillerP D Clarke
© 2021 Meta ULC. All rights reserved