PMID: 9184394May 1, 1997Paper

Hepatitis G viral RNA in serum and in peripheral blood mononuclear cells and its relation to HCV-RNA in patients with clotting disorders

Thrombosis and Haemostasis
L ShengS H Yap

Abstract

The hepatitis G virus (HGV) has recently been identified as a new member of the Flaviviridae family. Infection by this virus is thought to be associated with blood borne hepatitis. In this study, the presence of HCV- and HGV-RNAs in serum or plasma (175 patients) and in peripheral blood mononuclear cells (PBMC) (133 patients) was investigated in patients with clotting disorders using a sensitive reverse transcriptase polymerase chain reaction (RT-PCR). HGV-RNA was detected in serum of 26 patients (14.8%). In apparently healthy blood donors, serum HGV-RNA was detected in 4 of 358 individuals investigated (1.12%). Ninety two percent of the 26 serum HGV-RNA positive patients had coinfection with the hepatitis C virus (HCV), especially with HCV genotype 1b, the most common genotype in Belgium. Of these coinfected patients, 15 (62.5%) showed elevated serum ALT levels. Two patients who were solely infected with HGV had normal serum ALT.HGV-RNA in PBMC was found in 18 patients, of whom 3 were negative for serum HGV-RNA. As in case of HCV, HGV-RNA in PBMC is preferentially sensitive to interferon treatment. Nevertheless, rapid reappearance of HGV-RNA in PBMC was observed after cessation of treatment. In one patient, persistent serum AL...Continue Reading

Citations

Jan 24, 2003·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·S LiX Yang
May 5, 1998·Transfusion Medicine Reviews·K G Hadlock, S K Foung
Sep 19, 1998·Clinical and Diagnostic Virology·P KarayiannisH C Thomas
May 7, 1998·Transfusion Science·F AraújoL M Cunha-Ribeiro
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·J M Teitel
Dec 22, 2000·Blood Reviews·J P Allain

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