PMID: 9420302Jan 7, 1998Paper

Hepatitis G virus encodes protease activities which can effect processing of the virus putative nonstructural proteins

Journal of Virology
A S BelyaevJ P Kim

Abstract

The genome of a recently identified virus, hepatitis G virus (HGV), shows considerable homology to hepatitis C virus (HCV). Two HGV proteases similar to nonstructural proteins NS2 and NS3 of HCV were identified, and their cleavage site specificity was investigated. Amino acids essential for the protease activities were determined by mutation analysis. NS4A of HGV was demonstrated to be a cofactor for NS3-mediated proteolysis, with a region critical for activity residing between Leu1561, and Ala1598.

References

Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T A Kunkel
Jun 1, 1995·Nature Medicine·J N SimonsI K Mushahwar
May 1, 1995·Journal of Medical Virology·G G SchaluderT P Leary
Aug 1, 1994·Journal of Virology·R BartenschlagerH Jacobsen
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A GrakouiC M Rice
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·E PizziR De Francesco
Mar 2, 1996·Lancet·A J Zuckerman
Apr 4, 1997·The Journal of Biological Chemistry·A UrbaniA Pessi
Jul 1, 1997·Journal of Virology·E ScarselliC Traboni

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Citations

Aug 30, 2001·Scandinavian Journal of Infectious Diseases·R HalaszM Sällberg
Nov 16, 2002·Current Infectious Disease Reports·Sarah L. GeorgeJack T. Stapleton
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jinhua XiangJack T Stapleton
Sep 18, 2009·Journal of Viral Hepatitis·Emma L Mohr, Jack T Stapleton
Jun 19, 2012·Expert Review of Anti-infective Therapy·Carolynne Schwarze-ZanderJuergen K Rockstroh
Sep 24, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·T PérezI Haro
Jan 31, 2002·World Journal of Gastroenterology : WJG·N S XiaM Ng
Jun 11, 1999·Journal of Virology·P Simmonds, D B Smith
Aug 4, 2001·Biochemical and Biophysical Research Communications·Y J LeeW J Park
Aug 13, 1998·Journal of Medical Virology·L G BirkenmeyerI K Mushahwar
Mar 2, 1999·Biochemical and Biophysical Research Communications·R N CharrelX de Lamballerie

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