PMID: 9543362Apr 16, 1998Paper

Hepatitis G virus infection in children on dialysis and after renal transplantation

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
A SzaboU Heemann

Abstract

The aim of the present study was to use a combination of the reverse transcription-polymerase chain reaction and a new diagnostic test for antibodies against the viral envelope protein E2 to assess the prevalence of hepatitis G virus (GBV-C/HGV) infection in sera of Hungarian children on hemodialysis (HD) or peritoneal dialysis (CAPD), as well as in sera of renal transplant patients (RTx). The GBV-C/HGV RNA prevalence was significantly higher in the whole group of children with renal failure (18.5%) than in the control group (children with urinary tract infection, 2.5%). The difference between the GBV-C/HGV RNA prevalence in the RTx group (33.3%) and in the control group (2.5%) was significant (P = 0.007). Anti-E2, which is considered an indicator of a past GBV-C/ HGV infection, was detected in 10% (1/10) of HD patients, in 33.3% (4/12) of RTx patients, but in none of the children on CAPD. These differences were not significant. Children receiving a renal graft are at an increased risk of developing GBV-C/HGV infection, which may be attributed to the immunosuppressive drugs necessary to maintain the grafts.

Citations

Aug 25, 1999·Journal of Medical Virology·H KomatsuM Inui
Dec 18, 2009·Annals of Clinical Microbiology and Antimicrobials·Ayman Mohammad Hammad, Mohammad Hosam El Deen Zaghloul
May 14, 2009·Pediatric Hematology and Oncology·Khaled Mohamed Salama, Osima El-Sayed Selim
Aug 14, 2002·Journal of Paediatrics and Child Health·D J SiebertW Hardikar

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