Hepatitis G virus infection in patients transplanted for cryptogenic cirrhosis: red flag or red herring?

Transplantation
M R CharltonD H Persing

Abstract

The significance of hepatitis G (HGV) infection in liver transplant recipients is not known. We set out to determine the pre-orthotopic liver transplantation (OLT) prevalence, the pre- and postoperative viral titers of HGV, and the allograft histology in patients infected with HGV who underwent OLT for cryptogenic cirrhosis. HGV RNA was measured using a research-based branched DNA assay. The assay used a target-specific probe set that was based on the 5'-untranslated region of the HGV genome. Allograft histology was assessed with protocol liver biopsies in all patients who survived longer than 6 months. The preoperative prevalence of HGV infection in recipients transplanted for cryptogenic cirrhosis was 26%. Thirty-seven percent (12 of 33) of recipients who had serum available in the first postoperative month had HGV infection. Mean HGV RNA levels were 9.8 (+/-4.2) (viral molecular equivalents/ml x 10[6]) before OLT and 37.5 (+/-10.7) at 1 year after OLT. In 4 of the 11 cryptogenic recipients in whom HGV RNA was detectable in the first postoperative month, HGV RNA fell to undetectable levels at the most recent follow-up (mean 70 months). Of the five cryptogenic recipients who continue to have measurable HGV RNA, three have unex...Continue Reading

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Citations

Aug 13, 1998·Journal of Medical Virology·I K Mushahwar, J N Zuckerman
Sep 12, 2000·Current Gastroenterology Reports·K V Menon, N N Zein
Aug 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael A HeneghanJohn G O'grady
Aug 16, 2011·Transplantation Proceedings·J M ÁlamoF J Padillo
Apr 14, 1999·The American Journal of Gastroenterology·D J BrandhagenD H Persing

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