PMID: 9536822Apr 16, 1998Paper

Hepatitis G virus infection in primary Sjögren's syndrome: analysis in a series of 100 patients

Annals of the Rheumatic Diseases
Josep FontM Ingelmo

Abstract

To determine the prevalence and clinical significance of hepatitis G virus (HGV) infection in a large cohort of patients with primary Sjögren's syndrome (SS). The study included 100 consecutive patients (92 female and eight male), with a mean age of 62 years (range 31-80) that were prospectively visited in our unit. All patients fulfilled the European Community criteria for SS and underwent a complete history, physical examination, as well as biochemical and immunological evaluation for liver disease. Two hundred volunteer blood donors were also studied. The presence of HGV-RNA was investigated in the serum of all patients and donors. Additionally, HBsAg and antibodies to hepatitis C virus were determined. Four patients (4%) and six volunteer blood donors (3%) presented HGV-RNA sequences in serum. HGV infection was associated with biochemical signs of liver involvement in two (50%) patients. When compared with primary SS patients without HGV infection, no significant differences were found in terms of clinical or immunological features. HCV coinfection occurs in one (25%) of the four patients with HGV infection. The prevalence of HGV infection in patients with primary SS is low in the geographical area of the study and HCV coin...Continue Reading

Citations

Jul 10, 2003·Autoimmunity Reviews·Manuel Ramos-CasalsJosep Font
Jan 24, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Soheir ZakariaSerag Zakaria
Jan 23, 1999·Current Opinion in Rheumatology·J Braun, J Sieper
Jul 20, 1999·Current Opinion in Rheumatology·S R Ytterberg
Sep 30, 1999·Current Opinion in Rheumatology·R I FoxP Michelson
Feb 26, 2008·Autoimmunity Reviews·Damien SènePatrice Cacoub
Oct 19, 2006·Archives of Medical Research·Mario García-CarrascoRicard Cervera
Aug 29, 2006·World Journal of Gastroenterology : WJG·M IrshadI Dhar
Nov 21, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mana IizukaTakayuki Sumida
Sep 30, 2014·Microbiology and Immunology·Yan WangChengjin Hu

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