Hepatitis viruses in Kathmandu, Nepal: hospital-based study

BMC Research Notes
Birendra Prasad GuptaSantosh Chaudhary

Abstract

The objective of this study was to see the aetiology and outcome of sporadic acute viral hepatitis (AVH) in Kathmandu, Nepal. Among 210 patients, 94 (45%) were male and 116 (55%) were female. Mean age was 30 years. 52 (24.7%) out of 210 were positive for either of the hepatitis virus infection. Major causative agent for AVH among hepatitis positive patients were hepatitis E virus (HEV) in 36 (69.2%), followed by hepatitis A virus (HAV) 8 (15.3%), hepatitis B virus (HBV) 7 (13.4%) and hepatitis C virus (HCV) 1 (1.9%). The 158 (75.3%) patient were negative for all hepatitis viral markers. Co-infections with more than one virus were found in 4 (7.6%) patients. All liver-specific enzymes including bilirubin increased in hepatitis-infected patients. We found large number circulation of HEV in Kathmandu, Nepal, indicating that this region is endemic for hepatitis virus infection.

References

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Citations

Jul 30, 2021·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Sundar KhadkaShravan Kumar Mishra

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Methods Mentioned

BETA
RNA assay
PCR

Software Mentioned

Enzygnost
SPSS

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