Hepato-renal transport of phenolsulfonphthalein in analbuminemic rats: albumin is essential for hepatic compensatory elimination of a nephrophilic ligand in animals with renal dysfunction

Journal of Biochemistry
M InoueY Morino

Abstract

To investigate a possible function of plasma albumin in partitioning organic anions into bile and urine, phenolsulfonphthalein (PSP) was administered intravenously and its in vivo fate was studied in normal and analbuminemic mutant rats (NAR). No significant change in the rate of PSP disappearance was observed in bilaterally nephrectomized normal rats. However, biliary excretion of the injected dye increased remarkably in nephrectomized normal rats. Intravenously injected PSP disappeared very rapidly from the circulation of NAR. Thus, the plasma clearance and distribution volume of PSP were significantly larger in NAR than in normal rats. Bilateral nephrectomy also failed to decrease the plasma clearance and distribution volume of the dye in NAR. In striking contrast to the experiments in normal rats, bilateral nephrectomy did not increase the biliary secretion of PSP in NAR. When PSP bound to equimolar albumin was injected into bilaterally nephrectomized NAR, the biliary excretion of PSP increased significantly with concomitant decrease in both plasma clearance and distribution volume of the dye. These results indicate that, in cases of renal transport dysfunction, albumin plays a critical role in hepatic compensatory excretio...Continue Reading

Citations

Oct 1, 1992·Liver·C FleckH Bräunlich
Dec 4, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrei I IvanovAndrej A Romanovsky
Jul 28, 2007·Biopharmaceutics & Drug Disposition·Young H ChoiMyung G Lee
Oct 25, 2013·The Journal of Pharmacy and Pharmacology·Joo Hyun LeeEuichaul Oh
Feb 7, 2003·Life Sciences·Eun Jung KimMyung Gull Lee

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