PMID: 46275Jan 1, 1975

Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes

Journal of the National Cancer Institute
L A Poirier

Abstract

The effects of high dietary levels of lipotropes on the carcinogenic activity of diethylnitrosamine (DENA) in rats were studied. All animals given DENA, with or without a dietary supplement, developed hepatocellular carcinomas. The mean survival times of all groups of rats dying with hepatocellular carcinomas after DENA treatment were determined. Choline, betaine, and folic acid consistently exerted no significant effect on those mean survival times. In rats receiving approximately equal to 2 mg DENA/day, methionine administration led to a slight but significant increase in the mean survival time of the carcinogen-treated rats, whereas vitamin B12 significantly lowered the survival time; neither substance altered the mean survival times of those treated with only 1.0 mg DENA/day. On the other hand, ethanolamine decreased the mean survival times of rats given 1.0 mg DENA daily, but had no effect on animals receiving 2 ml/day of carcinogen. Dimethylthetin (sulfur analogue of betaine), methotrexate, lecithin, and cephalin exerted no effect on the carcinogenic activity of DENA. The administration of dimethylthetin and betaine along with DENA led to markedly increased liver weights in animals dying of hepatocellular carcinomas, when...Continue Reading

References

Mar 17, 2000·The Journal of Nutrition·S W Choi, J B Mason
Nov 15, 2014·Current Pathobiology Reports·Allyson K MartínezShannon S Glaser
Jan 1, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yan LiuSteven Dooley
Feb 22, 2012·Journal of Cellular Biochemistry·Zeynep Coban, Michelle Craig Barton
Apr 12, 2011·International Journal of Cancer. Journal International Du Cancer·Carlos Eduardo Andrade ChagasFernando Salvador Moreno
Jan 1, 1994·Nutrition and Cancer·S A Glynn, D Albanes

Related Concepts

Tumor Promoters
Diet
Citrate de Betaine UPSA
Liver Carcinoma
Lipocaic
Pedameth
Phosphatidylcholines
Ethanolamines
Choline Hydroxide
Methotrexate, (DL)-Isomer

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