Hepatocellular Adenomas: Morphology and Genomics

Gastroenterology Clinics of North America
Paulette Bioulac-SageCharles Balabaud

Abstract

Hepatocellular adenomas (HCAs) are rare benign tumors. This single entity has been split into 3 subtypes corresponding to specific mutations: HNF1α-inactivated HCA; inflammatory HCA related to different mutations, all leading to activation of STAT3 pathway; and β-catenin-activated HCA related to CTNNB1 mutations. The risk of malignant transformation depends on the level of β-catenin activation, reported mainly for exon 3, including S45. It is possible using specific immunohistochemical markers to identify the 3 different HCA subtypes and the level of β-catenin activation. Fewer than 10% of HCAs remain unclassified.

Citations

Sep 6, 2018·Histopathology·David CappellenPaulette Bioulac-Sage
Aug 21, 2018·The Journal of Clinical Endocrinology and Metabolism·Cemre RobinsonMichael T Collins
Dec 4, 2019·Nature Reviews. Gastroenterology & Hepatology·Amanda J CraigAugusto Villanueva
Feb 6, 2020·Journal of Insurance Medicine·David S Williams
Dec 12, 2020·Human Pathology·Aurélie Beaufrère, Valérie Paradis
Mar 25, 2019·Clinics and Research in Hepatology and Gastroenterology·Charles BalabaudPaulette Bioulac-Sage
Dec 1, 2020·Case Reports in Gastroenterology·Joris T HepkemaJoost M Klaase

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