PMID: 11933273Apr 5, 2002Paper

Hepatocellular carcinoma-fibrolamellar variant: cytopathology of an unusual case

Diagnostic Cytopathology
George KunzSyed Z Ali

Abstract

The fibrolamellar variant of hepatocellular carcinoma (FL-HCC) is an uncommon visceral malignancy with a distinctly better prognosis. An accurate initial diagnosis, therefore, is essential for prognostic and therapeutic reasons. This case report describes the cytomorphology of an unusual case of FL-HCC in a 13-yr-old boy who was found to have a hepatic mass with prominent intraluminal growth pattern seen predominantly in the right hepatic duct. A diagnosis of FL-HCC was originally suspected on bile duct brushings obtained during endoscopic retrograde choleangiopancreaticogram (ERCP) and subsequently confirmed on fine-needle aspiration (FNA) and surgical resection of the hepatic tumor. The cytomorphologic profile of FL-HCC is distinctive in the right clinical setting, allowing an accurate preoperative identification of this malignancy on biliary brushing or FNA.

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Citations

Jan 1, 2012·Scientifica·Michael Torbenson
Mar 25, 2016·The Indian Journal of Surgery·Valeriu ArdeleanuCostinela Georgescu
Jul 19, 2011·Cytopathology : Official Journal of the British Society for Clinical Cytology·A Wee
Apr 25, 2007·Advances in Anatomic Pathology·Michael Torbenson
Dec 30, 2015·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Alexandra KalogerakiEleni Moustou

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